An abstract of the study "Cyclic AMP dependent activation of Rac and PAK induced by the serotonin 5-HT4 receptor," by M. Maillet et al, is presented.MailletM.ZugazaJ.L.BertoglioJ.FischmeisterR.Lezoualc'hF.European Journal of Heart Failure...
Activation of cyclic AMP degradation. Using purified rat ventricular myocytes and membranes prepared from them, we have previously found that alpha 1-adrenergic stimulation causes decreased cyc... ILO Buxton,LL Brunton - 《Journal of Biological Chemistry》 被引量: 197发表: 1985年 Activation of ...
Cyclic AMP activated ERK1/2 in a time- and dose-dependent manner, and the effect was inhibited by PD098059, an inhibitor of the ERK1/2 signaling pathway. However, inhibition of protein kinase A (PKA) did not alter the activation of ERK1/2. CT transiently inhibited both staurosporine and...
Activation of the Cyclic AMP Pathway by ??-Melanotropin Mediates the Response of Human Melanocytes to Ultraviolet B Radiation A. Abdel-Malek (1998) Activation of the cyclic AMP pathway by a-melanotropin mediates the response of human melanocytes to ultraviolet B radiation. ... S Im,O Moro,F...
A decrease in cyclic AMP does not mediate the inhibition of [ 3 H]norepinephrine release in response to alpha-2 adrenergic receptor activation, although elevations in cyclic AMP can enhance electrically-stimulated release of [ 3 H]norepinephrine....
isolated from melanoma cells. The kinetics of the reaction in the cell-free system are similar to those in intact cells. The activation of tyrosinase is completely dependent on the protein kinase and is enhanced by cyclic AMP, ATP, and magnesium. The activation involves the removal of an ...
Endogenous cyclic GMP-AMP (cGAMP) binds and activates STING to induce type I interferons. However, whether cGAMP plays any roles in regulating metabolic homeostasis remains unknown. Here we show that exogenous cGAMP ameliorates obesity-associated metabol
The sequence motif CGTCA is critical for binding of a group of cellular transcription factors (ATF, CREB, E4F, and EivF) and for activation of certain E1a-inducible and cyclic AMP (cAMP)-inducible promoters. We have tested different promoter elements containing the CGTCA motif (referred to ...
(2015) found that c-di-GMP targeted to B16-F10 melanomas in this way led to the production of type I IFN and activation of NK cells. However, the purported anti-tumour effect is not convincing. The melanoma cells were injected into the tail vein. The introduction of liposomes containing ...
G protein–coupled receptors (GPCRs) are one of the most popular target classes investigated in the drug-discovery process. With its selection of kits (cAMP femto, cAMP dynamic and cAMP HiRange), Cisbio allows detection of a broad range of cyclic AMP concentrations. This is a prev...