protein language models (PLMs) are developed using extensive labeled and unlabeled datasets to create vectorized embeddings that represent both protein sequences and structures. This innovative method has been
We highlight CAMPER as a tool to facilitate detection of genes encoding polyphenol-active enzymes in genomic datasets, enabling researchers to begin addressing these questions in their datasets. As permafrost carbon stores face uncertain fates with changing climates, we must not assume that portions ...
One clear effect of pausing cells for long periods in G1 is that they become progressively enlarged in size, as the total cellular protein andRNAcontinue to increase despite thecell cycle arrest. This occurs in non-transformed hTERT-RPE1 cells (RPE1) and HR+/HER2− breast cancer cells tha...
The investigation revealed that modifying [Formula see text] could counteract fluctuations in the qDESS [Formula see text] mapping method's susceptibility to [Formula see text], consequently enhancing the detection of true biological variations. The robustness of bilateral qDESS [Formula see text] ...
Our findings contribute to the understanding of the aetiology and genetic context of G0 arrest in cancer. This is particularly relevant to not only identifying new anti-proliferative targets but also for the detection and eradication of drug-tolerant persister cells, which have been frequently, althou...
We next assessed differences in myeloid differentiation between treatment-resistant and sensitive tumors. Consistent with the detection of immune-suppressive cancer to myeloid communications, we found that macrophages in growing ribociclib-resistant tumors had greater M2-like differentiation prior to and thr...
carcinoma cell line harbors a defunct endogenous p53 and was stably transfected with tetracycline-responsive wild-type p53. RNA was isolated from cells grown in the presence of tetracycline (control) and 6 h after tetracycline removal (p53 induced). p53 induction is shown in Additional file1: ...
The cell cycle comprises a series of temporally ordered events that occur sequentially, including DNA replication, centrosome duplication, mitosis, and cytokinesis. What are the regulatory mechanisms that ensure proper timing and coordination of events d
Detection and removal of barcode swapping in single-cell RNA-seq data Nat. Commun., 9 (2018), p. 2667 View in ScopusGoogle Scholar Hafemeister and Satija, 2019 C. Hafemeister, R. Satija Normalization and variance stabilization of single-cell RNA-seq data using regularized negative binomial re...
Conversely, restoring PKP2 in inflamed adipocytes rewires E2F signaling towards the re-activation of cell cycle and decreased senescence. Our findings connect the expression of PKP2 in fat cells to the physiopathology of obesity, as well as uncover a previously unknown defect in cell cycle and ...