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In addition, we observe that pharmacological inhibition of MVA pathway by simvastatin is sufficient to inhibit CYB5R3 translocation and induces smooth muscle death. Therefore, we conclude that the dysregulation of MVA intermediates is an essential mechanism for metaflammation initiation, in which the ...
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GGPP depletion initiates metaflammation through disequilibrating CYB5R3-dependent eicosanoid metabolismdoi:10.1074/JBC.RA120.015020Lisha WeiYan-Yan ZhengJie SunPei WangTao TaoYeqiong LiXin ChenYongjuan SangDanyang ChongWei ZhaoElsevier
T. (2008) Functional characterization of human duodenal cyto- chrome b (Cybrd1): Redox properties in relation to iron and ascorbate metabolism. Biochim. Biophys. Acta 1777, 260-268.Oakhill, J.S.; Marritt, S.J.; Gareta, E.G.; Cammack, R.; McKie, A.T. Functional characterization of...