PD-1+ CXCR5+ CD4 T cells were functional, could express IL-21, IL-10, and CXCL13 upon stimulation, demonstrated auxiliary effects toward CD8 T cell-mediated IFN-纬 production and proliferation, and promoted IgM and IgG production. However, the potency of PD-1+ CXCR5+ CD4 T cells was ...
B cellsT cellsANTIBODY formationGERMINAL centersMany autoimmune diseases are characterized by the production of autoantibodies. The current view is that CD4 T follicular helper (Tfh) cells are the main subset regulating autoreactive B cells. Here we report a CXCR5PD1 Tfh subset of CD8 T cells ...
The induction of antibody responses by B cells is critical for protective immunity against infections and requires CXCR5+PD-1++ CD4+ T cells (TFH cells). We investigated the ontogeny of CXCR5+PD-1++ CD4+ T cells in human intestines. While CXCR5+PD-1++ CD4+ T cells were absent in fetal...
目的动态观测恩替卡韦治疗HBeAg阳性慢性乙型肝炎病毒携带者的临床疗效及其外周血PD-1 +CXCR5 +CD4 +T淋巴细胞、可溶性程序性死亡受体1(sPD-1)水平变化并探讨其临床意义。 方法慢性乙型肝炎病毒携带者治疗(A)组31例,慢性乙型肝炎患者治疗(B)组32例,慢性乙型肝炎病毒携带者未治疗(C)组15例,收集并比较3组患者0周...
CXCL13-producing PD-1hiCXCR5CD4 T cells were discovered in synovial tissues of rheumatoid arthritis (RA). Further intensive analysis of RA samples led to the proposal of PD-1hiCXCR5CD4 T cells as a pathogenic CD4 subset, peripheral helper T (Tph) cells. Tph cells are upregulated also in ...
PD-1hi CD4+ T cells was analysed by multicolour flow cytometry. The frequencies of circulating CXCR5?PD-1hi T cells were analysed in a cohort of 44 children with newly diagnosed type 1 diabetes, 40 autoantibody-positive (AAb+) at-risk children and 84 autoantibody-negative healthy control chil...
Programmed death 1 (PD-1), a negative T cell regulator to maintain peripheral tolerance, induces negative signals to T cells during interaction with its ligands. PD-1CD4T cells could be divided into PD-1CXCR5CD4T peripheral helper cells and PD-1CXCR5CD4 T (Tfh) cells according to CXCR5 ...
Importantly, the key effector cells of the CXCL13/CXCR5-associated immune axis express PD-1, hence attracting increasing interest as secondary or ancillary targets of anti-PD-1 therapy in different cancer types. As circulating counterparts of these effector cells are detectable in blood, the effects...
Importantly, the key effector cells of the CXCL13/CXCR5-associated immune axis express PD-1, hence attracting increasing interest as secondary or ancillary targets of anti-PD-1 therapy in different cancer types. As circulating counterparts of these effector cells are detectable in blood, the effects...
Percentage of TFH and expression of CXCR5 and PD-1 during fingolimod treatment in MS patients.Nele ClaesTessa DhaezeJudith FraussenBieke BrouxBart Van WijmeerschPiet StinissenRaymond HuppertsNiels HellingsVeerle Somers