400050） 摘要：趋化因子CXCL14是一种高度保守的趋化因子，在正常皮肤上皮中大量表达，除了参与细胞增殖、迁徙，血管生成，肿瘤抑制等生物学活动外，CXCL14在细菌、病毒、衣原体、寄生虫等感染性疾病中发挥调节作用，并具有广谱抗菌活性。此外，CXCL14对活化的巨噬细胞，未成熟的树突状细胞和自然杀伤细胞等具有化学吸引...
View Larger ImageCXCL14 Exerts Paradoxical Effects on Tumorigenesis.CXCL14 exhibits contradictory effects on tumorigenesis under different experimental conditions.In vitro, CXCL14 promotes breast and pancreatic tumor cell invasion and inhibits vascular endothelial cell (EC) migration.In vivo, overexpression ...
CXCL14 exhibited high expression levels in tumor tissues within the TCGA database (Fig.1A). However, the Overall Survival and Disease-Free Survival rates did not show statistically significant differences between patients with high and
www.nature.com/scientificreports OPEN Global Gene Expression Analysis in an in vitro Fibroblast Model of Idiopathic Pulmonary Fibrosis Received: 25 August 2017 Accepted: 13 February 2018 Published: xx xx xxxx Reveals Potential Role for CXCL14/ CXCR4 Luis R. Rodriguez 1, Margaret Emblom-...
Fibroblast growth factor receptor 1 activation in mammary tumor cells promotes macrophage recruitment in a CXCL1-dependent manner. PLoS One 2012; 7: e4... JR Reed,MD Stone,TC Beadnell,... - 《Plos One》 被引量: 47发表: 2012年 A practical approach to the understanding and diagnosis of ly...
basicfibroblastgrowthfactor,andvascularendothelialgrowthfactor.Invitro,rBRAKblockedendothelialcellchemotaxisatconcentrationsaslowas1nmol/L,suggest-ingthiswasamajormechanismforangiogenesisinhibition.AlthoughonlylowaffinityreceptorsforBRAKcouldbefoundonendothelialcells,humanimmaturemonocyte-deriveddendriticcells(iDCs)boundrBRAK...
it also inhibits angiogenesis in some cancers. A study conducted by Shellenbergeret al.has shown that recombinant CXCL14 inhibited chemotaxis of humanendothelial cellsandneovascularizationinduced by IL-8, VEGF, andfibroblast growth factor(FGF). In terms of mechanism, it has been speculated that CXC...
Although fibroblast-derived CXCL14 has a tumor-supportive role, epithelial-derived CXCL14 mainly inhibits tumor progression. Hence, this review will elucidate what is known on the mechanisms of CXCL14 and its therapeutic approaches in tumor treatment. CXCL14 is a promising approach for cancer ...
26 CXCR3A and its IFN-inducible ligands CXCL9 and CXCL10 regulate vascular 27 remodelling and fibroblast motility. IL-13 is a pro-fibrotic cytokine implica... J Worrell,S Walsh,A Fabre,... - 《Ajp Cell Physiology》 被引量: 0发表: 2020年 用于炎性疾病的抗-CXCL9,抗-CXCL10,抗-CXCL1...
Cancer-associated fibroblast-derived CXCL14 enhances tumour growth in mouse models of prostate and breast cancer. However, the prognostic significance of compartment-specific expression of CXCL14 has not been studied. CXCL14 mRNA expression was analysed in a breast cancer tissue microarray (TMA) of...