Diamond on the role of CXCL12/CXCR4 chemokines in the activation and migration of osteoclast (OC) associated with bone loss in multiple myeloma (MM) in mice published in the same issue. They note that the study found that targeted disruption of the genes inhibits osteolysis....
CXCL12 (SDF1{alpha})—CXCR4/CXCR7 pathway inhibition: an emerging sensitizer for anti-cancer therapies? Clin Cancer Res 2011; 17: 2074–2080. Article CAS Google Scholar Muller A, Homey B, Soto H, Ge N, Catron D, Buchanon M et al. Involvement of chemokine receptors in breast cancer ...
CXCL12 (SDF1{alpha})—CXCR4/CXCR7 pathway inhibition: an emerging sensitizer for anti-cancer therapies? Clin Cancer Res 2011; 17: 2074–2080. Article CAS Google Scholar Muller A, Homey B, Soto H, Ge N, Catron D, Buchanon M et al. Involvement of chemokine receptors in breast cancer ...
We provide further evidence that disruption of CXCL12/CXCR4 signaling in the bone marrow is a key step in HPC mobilization. G-CSF regulates CXCL12 expression in the bone marrow primarily at the mRNA level. Evidence is provided that G-CSF inhibits osteoblast number and activity through an ...
1a), as manifested by an increase in osteoclast number as well as larger subchondral bone marrow cavities at 2 weeks, and subsequently a decrease in the osteoclast number to baseline at 6 weeks after surgery (Fig. 1d, e). The number of Osterix+ cells, however, was continuously elevated ...
Despite the potential intriguing role of chemokines in the regulation of osteoclast (OC) functions, little is known about the expression of chemokines and their receptors in human OCs at different stages of differentiation. Therefore, we analyzed the expression of CXC chemokine receptors (CXCR1, ...
OSTEOCLAST inhibitionBONE disease geneticsThe article discusses the results of a study on the role of CXCL12/CXCR4 chemokines in the activation and migration of osteoclast (OC) associated with bone loss in multiple myeloma (MM) in mice. The study found that overexpression of CXCL12 and RANKL ...
CXCL12 (stromal cell-derived factor 1) is a unique biological ligand for the chemokine receptor CXCR4. We previously reported that treatment with a specific CXCR4 antagonist, AMD3100, exerts a beneficial effect on the development of collagen-induced arthritis (CIA) in the highly susceptible IFN-...
Adipocytes enhance expression of osteoclast adhesion-related molecules through the CXCL12/CXCR4 signalling pathway. Cell. Prolif. 2017, 50, e12317. [CrossRef] [PubMed]Luo T, Liu H, Feng W, Liu D, Du J, Sun J et al. (2017) Adipo- cytes enhance expression of osteoclast adhesion-related...
CXCL12 is primarily a homeostatic chemokine that induces migration and activation of hematopoietic progenitor cells, endothelial cells, and several leukocytes through interaction with CXCR4, ACKR1, and ACKR3. Thereby, it is an essential player in the regulation of embryogenesis, hematopoiesis, and ...