1. Ghosh S, et al. Targeting the CXCL1/CXCR2 axis in acute myeloid leukemia: challenge and promise. Blood, 2020;136(3):290-295. 2. Wengner AM, et al. CXCL1 induces senescence in human endothelial cells through the induction of the tumor suppressors p53 and p16INK4a. Molecular Cancer...
Our results indicated that CXCL1-CXCR2 axis might play an important role in mediating neutrophils recruitment in oral mucosa, which will give new insights into the mechanisms of innate and adaptive immune responses of oral mucosa.Tong WuDepartment of Oral MedicineHong WangDepartment of Stomatology...
Clinicopathologic significance of the CXCL1-CXCR2 axis in the tumor microenvironment of gastric carcinoma[J]. PLoS one, 2017,12(6):e0178635. DOI: 10.1371/journal.pone.0178635 . 返回引文位置Google Scholar 百度学术 万方数据 [33] Wang Z , Wang Z , Li G ,et al. CXCL1 from tumor-...
Thus, our results suggest that after sciatic nerve injury, the CXCL1-CXCR2 axis mediates the inflammatory response by promoting the recruitment and activation of macrophages, which is detrimental to the repair of the injured nerves. In contrast, treatment with SB225002 promotes the repair of ...
Blocking the CXCL1-CXCR2 axis enhances the effects of doxorubicin in HCC by remodelling the tumour microenvironment via the NF-kappaB/IL-1beta/CXCL1 signalling pathway. Cell Death Dis. 2023;9(1):120. Article CAS Google Scholar Nan J, Du Y, Chen X, Bai Q, Wang Y, Zhang X, et al...
However, in the PS region, the density of CD15+ cells was only correlated with CXCL1 expression (R = 0.391, P = 0.033; Fig. 3). These findings indicated that the CXCL1–CXCR2 axis may play an important role in promoting CD15+ neutrophil accumulation in HCC tumors....
Our results indicated that CXCL1-CXCR2 axis might play an important role in mediating neutrophils recruitment in oral mucosa, which will give new insights into the mechanisms of innate and adaptive immune responses of oral mucosa. 展开 关键词: Neutrophils Recruitment CXCL1 CXCR2 Oral Mucosa ...
Meanwhile, CXCL1–CXCR2 axis is overactivated in gastric cancer and is closely correlated with the migration and invasion ability of malignant cells16. By comparing the profiles of secreted proteins in low- and high-grade invasive balder cancer, CXCL1 was identified as the most significantly ...
Methyltransferase like 3 induces the N6-Methyladenosine-BHLHE41-CXCL1/CXCR2 axis to recruit myeloid-derived suppressor cells in the colorectal cancer immune microenvironment. Methyltransferase like 3 loss in colorectal cancer compromises its ability to drive myeloid-derived suppressor cell accumulation and ...
IL-8是炎症的重要驱动力,作用于其同源受体CXCR1和CXCR2。小鼠基因组中缺少IL-8基因,使得对这种趋化因子功能的研究更加困难,尽管它被认为是细菌防御和自身免疫的重要介质。在癌症中,IL-8介导多种致病作用,因为它能够将巨噬细胞和粒细...