In addition, our results provide insights into how a G-protein-coupled receptor is activated by an endogenous protein molecule, which will assist in the rational development of therapeutics that target the chemokine system for better pharmacological profiles. This is a preview of subscription content,...
Results Inhibition of constitutive CXC-chemokine signalling confers cell-specific ansamycin-induced cytotoxicity in CRPC cells Our experiments were conducted on two representative models of CRPC, the PC3 and DU145 cell lines. 3-(4, 5 -Dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide assays ...