results suggest that this Hsp90-targeted agent is cytotoxic to PC3 cells by promoting both necrotic and apoptotic cell death, mechanisms that seem to be selectively induced in response to low and high concentrations of 17-AAG, respectively. Our results suggest that inhibition of CXCR2 signalling ...
performed coarse-grained MD simulation and analysed the results. M.W. and S.Z. performed the molecular docking. Y.X. performed the functional assay. Q.S. assisted with cryo-EM data collection. Z.-J.L. and T.H. conceived the project, supervised the overall studies, analysed the ...