(ELISA)检测血清中ZO-1水平,采用Pearson相关性分析CX43,ZO-1表达与临床指标的相关性,采用受试者工作特征曲线(ROC)评价血清CX43,ZO-1对CHD合并DM发生的诊断价值;采用多因素Logistic回归分析影响CHD合并DM发生的危险因素.结果 CHD合并DM组患者血清中ZO-1的表达水平为(3.85±0.61) ng/m L,明显高于CHD组的(2.48±...
Cx43磷酸化及其与ZO-1、Src相互作用的研究进展
Effect of total saponins of Panax notoginseng on expression of ZO-1, Occludin, Cx43 proteins in myocardium after myocardial ischemia reperfusion injury [J]. J Chin Med, 2023, 42(3): 239-243, 260. [25] 张春燕, 杨倩 . 金丝桃苷预处理对心肌缺血再灌注性心 律失常大鼠心肌 ATP 酶活性和 Cx...
研究发现,在肿瘤和转化细胞中,普遍存在Cx43表达异常、细胞间隙通信(GJIC)功能缺陷,这与Cx43合成、运输、定位等过程多种相关蛋白有关1720.本文就细胞骨架蛋白、非受体酪氨酸蛋白激酶Src、细胞支架蛋白(ZO-1)及泛素蛋白成员CIP75等相关蛋白与Cx43相互作用,及其对细胞间连接通信的影响作一综述.1 、Cx43与细胞骨架蛋白...
ZO-1 is the major connexin-interacting protein in ROS 17/2.8 (ROS) osteoblastic cells. We examined the role of ZO-1 in Cx43-mediated gap junction formation and function in ROS cells that expressed the connexin-interacting fragment of ZO-1 (ROS/ZO-1dn) cells. Expression of this ZO-1(7...
第一,伤口愈合过程中Cx43表达水平及磷酸化水平可能会选择性地使一些间隙通道穿过分子通过,从而影响角化细胞的增殖和分化[36,37];第二,间隙连接蛋白除了具有组成间隙连接通道执行物质和信息交流的功能外,还能够与其他分子,如黏着分子、细胞骨架蛋白、ZO-1等结合调控细胞的运动和迁移[10,38,39]。所以伤口处下调Cx43...
科研热词针刺连接蛋白43缝隙连接蛋白43缝隙连接心律失常连接蛋白类脑血管痉挛缝隙连接蛋白cx43抗心律失常肽心肌细胞基因敲除原发性痛经内脏痛催产素受体rna干扰cx43颗粒物闰盘长qt综合征针刺镇痛原理针刺镇痛连接蛋白血管加压素受体蛋白表达肺静脉肌袖缝隙连接通讯缝隙连接蛋白zo-1缝隙连接蛋白经脉空气污染穴位磷酸化痛经电磁...
Injury-triggered Akt phosphorylation of Cx43: a ZO-1-driven molecular switch that regulates gap junction size The proteins that form vertebrate gap junctions, the connexins, are highly regulated and have short (<2 hour) half-lives. Phosphorylation of connexin43 (Cx... CA Dunn,PD Lampe - 《...
Connexin-43 interactions with ZO-1 and alpha- and beta-tubulin Cell Commun. Adhes., 8 (4–6) (2001), p. 219-23 Google Scholar [152] A. Saidi Brikci-Nigassa, et al. Phosphorylation controls the interaction of the connexin43 C-terminal domain with tubulin and microtubules Biochemistry, ...
A ZO1 binding-incompetent variant of αCT1, αCT1-I, indicated that these effects on barrier function and barrier-associated proteins, were likely associated with Cx43 CT sequences retaining ability to interact with ZO1. These results implicate the Cx43 CT and its interaction with ZO1, in ...