in the abdomen, especially on the intestines, in TAM-injectedCx3cr1CreERT2:Atg7fl/flmice, but not in the other groups (Fig.1d and Supplemental Movies 1, 2, 3 and 4). Indeed, quantitative analysis of the intestinal adhesion score according to Nair’s adhesion scale [16] (Table1) indic...
Cx3cr1CreERT2 mice express Cre recombinase in a tamoxifen-inducible manner and have been widely used to delete target genes in microglia, since microglia are long-lived cells and outlive peripheral macrophages, which continuously turn over and lose their gene modification over time. ATG7 is an ...
Cx3cr1-Flox 品系名:C57BL/6Smoc-Cx3cr1em1(flox)Smoc 品系状态:活体 | 目录号:NM-CKO-226496 Cx3cr1-CreERT2 品系名:C57BL/6Smoc-Cx3cr1em1(creERT2-WPRE-polyA)Smoc 品系状态:活体 | 目录号:NM-KI-200157 Cx3cr1-2A-EGFP 品系名:C57BL/6Smoc-Cx3cr1em1(P2A-EGFP)Smoc ...
Lee et al. Molecular Brain (2020) 13:88 https://doi.org/10.1186/s13041-020-00630-4 MICRO REPORT Open Access Cx3cr1CreERT2-driven Atg7 deletion in adult mice induces intestinal adhesion Younghwan Lee1, Ji-Won Lee1, Hyeri Nam1 and Seong-Woon Yu1,2* Abstract Microglia are macrophages ...
To study the role of ATG7 in adult microglia, we generated Cx3cr1CreERT2:Atg7fl/fl mice and deleted Atg7 at the age of 8 weeks, and found induction of intestinal adhesion. Since intestinal adhesion is caused by excessive inflammation, these results suggest that deletion of Atg7 in ...
Cx3cr1-Flox 品系名:C57BL/6Smoc-Cx3cr1em1(flox)Smoc 品系状态:活体 | 目录号:NM-CKO-226496 Cx3cr1-CreERT2 品系名:C57BL/6Smoc-Cx3cr1em1(creERT2-WPRE-polyA)Smoc 品系状态:活体 | 目录号:NM-KI-200157 Cx3cr1-2A-EGFP 品系名:C57BL/6Smoc-Cx3cr1em1(P2A-EGFP)Smoc ...