今天要讲的这篇文献是2023年5月在cell reports上发表的一篇文章,名字是CX3CR1himacrophages sustain metabolic adaptation by relieving adipose-derived stem cell senescence in visceral adipose tissue。 我们都知道在短期营养过剩时,脂肪细胞可以通过增生或肥大完成适应性扩张,储存更多的甘油三酯。ASC是脂肪组织内的干...
We demonstrate that a population of CX3CR1hi macrophages is maintained in mouse VAT during short-term energy surplus, which sustains ASCs by restraining their senescence, driving adaptive VAT expansion and metabolic health. Long-term overnutrition induces diminishment of CX3CR1hi macro-phages in ...
However, recent evidence shows that very early during infection, pathogen-capturing CX3CR1+ macrophages migrate to the lumen of the small intestine, therefore preventing pathogens from traversing the epithelium. Here we discuss the complexity of the at-times seemingly opposing roles played by these ...
近年来,大量研究发现肿瘤微环境中的髓系细胞如肿瘤相关巨噬细胞(tumor-associatedmacrophages,tam)和髓系来源抑制性细胞(myeloid-derived suppressive cell,mdsc)等是抑制t细胞功能,介导免疫治疗抵抗的主要细胞群体。巨噬细胞和单核细胞可过表达pd-l1和t细胞上抑制性受体的靶向配体,从而触发t细胞衰竭,也可通过分泌il-10...
2023年12月24日,汪世龙教授课题组在线发表题为“Advanced Functional Materials Anion-Dependent Layered Double Hydroxide Nanoparticles Regulate Differentiation of CD206+ CX3CR1+ Macrophages by Inhibiting the IL-17 Signaling Pathway Contributing to Inflammatory Bowel Disease”的研究论文,该研究发现了阴离子依赖的...
2023年12月24日,汪世龙教授课题组在线发表题为“Advanced Functional Materials Anion-Dependent Layered Double Hydroxide Nanoparticles Regulate Differentiation of CD206+ CX3CR1+ Macrophages by Inhibiting the IL-17 Signaling Pathway Contributing to Inflammatory Bowel Disease”的研究论文,该研究发现了阴离子依赖的...
CX3CR1 (CX3C chemokine receptor 1; also known as fractalkine receptor, GPCR13 and V28) is a 40 kDa member of the δ-group of rhodopsin GPCRs. It is expressed on astrocytes, microglia, macrophages, Th1 and Tc1 T cells, NK cells, mouse Gr1lomonocytes plus smooth muscle and mast cells...
CX3CL1is the sole member of the CX3C family and also known asFractalkine(FKN). It is mainly expressed by macrophages, endothelial cells, platelets, and smooth muscle cells, involved in various inflammatory processes.CX3CR1is the G protein-coupled receptor binding to CX3CL1, and their intera...
patterns2,3. The origin of Kupffer cells has been intensively studied but remains undefined. Fate-mapping recently revealed that several tissue-specific macrophages originate from either the yolk sac or fetal hematopoietic stem cells and proliferate locally4,5,6. Other findings indicate that Kupffer ...
今天要讲的这篇文献是2023年5月在cell reports上发表的一篇文章,名字是CX3CR1himacrophages sustain metabolic adaptation by relieving adipose-derived stem cell senescence in visceral adipose tissue。 我们都知道在短期营养过剩时,脂肪细胞可以通过增生或肥大完成适应性扩张,储存更多的甘油三酯。ASC是脂肪组织内的干...