Chronic wasting disease (CWD), a prion disease of cervids, spreads efficiently among wild and farmed animals. Potential transmission to humans of CWD is a growing concern due to its increasing prevalence. Here, we provide evidence for a zoonotic potential of CWD prions, and its probable ...
T. et al. Chronic wasting disease in cervids: Implications for prion transmission to humans and other animal species. MBio 10, e01091-e1119 (2019). Article Google Scholar Prusiner, S. B. Novel proteinaceous infectious particles cause scrapie. Science 216, 136–144 (1982). Article ADS CAS...
The researchers found that there is no new CWD propagation or deposition of protease-resistant forms of human prions in the CWD-exposed organoids, which had remained uninfected for up to 6 months, suggesting substantial species barrier prevents the transmission of CWD to humans. ...
To date there are no confirmed cases of CWD transmission from wildlife to domestic animals or from cervids to other wild ungulate species. There is also no scientific evidence of CWD being transmitted from cervids to humans. Research conducted in 2022 and 2023 by National Institutes of Health...
While Nevada may seem to have a low density of deer that may limit transmission, in some areas we have high concentrations of deer on winter range. Contact between males on winter range is the main driver of CWD prevalence. There is currently no evidence to indicate that CWD can be ...
p> Transmission of chronic wasting disease (CWD) between cervids is influenced by the primary structure of the host cellular prion protein (PrP C ). In white-tailed deer, PRNP alleles encode the polymorphisms Q95 G96 (wild typ... C Duque Velásquez,C Kim,A Herbst,... - 《Journal of...
Anytime animals are concentrated at this type of "hub," the likelihood of disease transmission increases in a deer herd. More alarming, the transferring of CWD prions to healthy deer is not the only concern. Diseases such as bovine tuberculosis, foot rot bacteria, fungal pathogens, hemorrhagic ...
has raised increasing public health concerns about the possible transmission to humans of a TSE among deer and elk known as chronic wasting disease (CWD)... JP Davis,J Kazmierczak,M Wegner,... - 《Morbidity & Mortality Weekly Report》 被引量: 23发表: 2003年 ...
transmission. To date, ten CWD strains have been characterized. The expanding range of CWD in North America and its presence in South Korea as well as Scandinavian countries will potentially result in millions of cervids infected with CWD; thus, novel strains will continue to emerge. In this ...
Strain emergence can occur following transmission to novel host–PrPC environments (6, 8, 9); the mechanism behind this adaptive response, however, remains unclear (9, 10). Prion conformers have been postulated to “mutate” by deformed-templating (11). We hypothesize a prion strain is a ...