Respiratory syncytial virus (RSV) is an important respiratory pathogen in infants and children worldwide. Although RSV typically causes mild upper respiratory infections, it frequently causes severe morbidity and mortality, especially in premature infants and children with other chronic diseases. Treatment ...
2000). In chimpanzees, the level of replication of both RSVA2ΔNS1 and RSVA2ΔNS2 is reduced greater than 10 000-fold in the lower respiratory tract. In the upper respiratory tract, the ΔNS1 virus is more attenuated than the ΔNS2 virus (Teng et al., 2000). Deletion of the M2 ...
Viral croup usually begins with mild symptoms of an upper respiratory infection-low—grade fever, runny nose, and mild cough. The child awakes from a nap or during the middle of the night with a barking cough and discomfort from a sore throat. Inspiratory stridor is often the symptom that ...
A. Inhibition of respiratory virus infection by locally applied interferon. Lancet 301, 563–567 (1973). Google Scholar Scott, G. M. et al. Prevention of rhinovirus colds by human interferon α-2 from Escherichia coli. Lancet 320, 186–188 (1982). Google Scholar Higgins, P. G. et ...
Respiratory syncytial virus (RSV) is a negative-sense, single stranded RNA virus and a member of the Paramyxoviridae family.1 The viral envelope of RSV contains three proteins, the G glycoprotein, ...
The recent pandemic which arose from China, is caused by a pathogenic virus named “severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2)”. Its rapid global expansion has inflicted an extreme public health concern. The attachment of receptor-binding domains (RBD) of the spike pro...
Respiratory syncytial virus infects most children before the age of two and is a leading cause of lower respiratory tract infections in infants, particularly bronchiolitis and pneumonia, and has also been implicated in the later life development of asthma17,18. Recent estimates suggest that RSV is...
A key question for infectious disease dynamics is the impact of the climate on future burden. Here, we evaluate the climate drivers of respiratory syncytial virus (RSV), an important determinant of disease in young children. We combine a dataset of county-level observations from the US with sta...
and naringenin, have exhibited broad-spectrum antiviral activity toward a wide range of enveloped (hepatitis B virus [HBV], HCV, HIV, African swine fever, influenza A, dengue, respiratory syncytial and Newcastle disease virus [NDV]) and nonenveloped (foot and mouth disease and enterovirus) virus...
FIPV = feline infectious peritonitis virus. In studies of SARS-CoV and MERS-CoV in human respiratory epithelial cell cultures, remdesivir has demonstrated strong antiviral activity (EC50≈ 0.07 μM for either virus) with relative consistency, and has been shown to be capable of inhibiting MERS-CoV...