Diabetic neuropathy (DN) is a group of multifactorial disorder in diabetic patients, which affects neuronal function of the whole body and is accompanied by nephropathy and angiopathy. Its prevalence increases with duration of diabetes and hyperglycaemia which can induce oxidative stress resulting in ...
With respect to the pharmacologic management of DPN, treatments generally fall into 2 main categories: those treatments that provide symp- tomatic relief for the pain, burning, paresthesias, numbness, and tingling that mark this condition, and those that actually influence the natural history of ...
CLOSING THE GAP FOR PHARMACOLOGICAL TREATMENT OF PAINFUL DIABETIC NEUROPATHY : THE POTENTIAL ROLE OF VITAMIN D Painful neuropathic pain is a challenging chronic pain to treat. It is heterogeneous in symptoms and could be resistant to the available treatments regimen... RT Pinzon,A Angela - 《Malan...
It also recommends that PAD patients with critical limb ischemia (CLI) should be considered to receive endovascular and open surgical treatment for limb salvage. Although PAD patients with CLI receive these treatments, they are sometimes unable to deliver sufficient blood flow to eliminate their ...
Since oxidative stress leads such a major role in the development of diabetic neuropathy, a large number of antioxidants have been tested in experimental models, many of which have reached clinical trials as well. Moreover, novel strategies such as employing antioxidant which specifically reduce ...
Current treatments include standard immunosuppressive agents, such as corticosteroids and cyclophosphamide, plasmapheresis, intravenous immunoglobulin, thalidomide, and intratechal treatment; however, more directed therapy, such as tumor necrosis factor-alpha blocking agents may hold promise in rhe...
Clinical studies are an important step in discovering new treatments for diseases and the role of clinical trials is to inform about safety, accuracy, and evidence-based medicine [138,147]. Recent years have seen a rise in clinical studies that make use of natural ingredients [28]. In recent...
Considerations Regarding Association of Semaglutide and Nonarteritic Anterior Ischemic Optic Neuropathy Jim Shenchu Xie, MD; Jonathan Trobe, MD; Edward Margolin, MD Abstract Full Text JAMA Ophthalmol. 2024;142(12):1174. doi:10.1001/jamaophthalmol.2024.4518 Invited Commentary Semaglutide and Nonart...
Objective We previously designed and reported a simple new method (the cold-loaded pain sensation test) for quantitative evaluation of the function of small nerve fibers. In the study reported here, we investigated the clinical usefulness of this test to evaluate diabetic neuropathy by comparison wit...
Association between Glucose-Lowering Treatments and Risk of Diabetic Retinopathy in People with Type 2 Diabetes: A Nationwide Cohort Study. April 20, 2023 [ MEDLINE Abstract ] A Case Report of Cefixime, Paracetamol, and Nimesulide Induced Toxic Epidermal Necrolysis in a Woman with Dengue Infecti...