Current treatment strategies for multiple myeloma. Clin Lymph Myeloma. 2007; 7(4): 139-144.Thomas S, Alexanian R. Current treatment strategies for multiple myeloma. Clin Lymph Myeloma. 2007; 7 (Suppl 4:S139–S144.Thomas, S. and R. Alexanian. Current treatment strategies for multiple myeloma...
The treatment of multiple myeloma (MM) continues to evolve rapidly with arrival of multiple new drugs, and emerging data from randomized trials to guide therapy. Along the disease course, the choice of specific therapy is affected by many variables including age, performance status, comorbidities, ...
Recent years have witnessed tremendous advances in the molecular pathogenesis and management of multiple myeloma. Standard chemotherapy (melphalan and prednisone; MP) has been the mainstay of treatment of multiple myeloma for about 3 decades. However, it is no longer considered the ‘gold standard’...
The introduction of novel molecular targeting agents against multiple myeloma has dramatically and rapidly changed the therapeutic strategies for this incu
The use of mAbs targeting PD-1/PD-L1 has been tested in the preclinical setting, with anti-myeloma activity demonstrated using an anti-PD-L1- based treatment protocol.95 The anti-PD-1 mAb most advanced in the clinic is nivolumab, although monotherapy with this agent has thus far achieved ...
Treatment for multiple myeloma has evolved to include treatment of precursor stages (early treatment) as these therapies are shown to be safe and effective also in smoldering myeloma. Randomized studies have shown that early treatment can delay the onset of multiple myeloma and even improve overall ...
Smoldering multiple myeloma (SMM) consists of the presence of a serum M protein of 30 g/L or more and/or 10% or more bone marrow plasma cells (BMPCs), with
As such, it is safe to conclude that ASCT can improve outcomes whether performed as first line or as a rescue treatment1,101. Therefore, frontline ASCT remains the standard of treatment for fit, young and select elderly patients with newly diagnosed multiple myeloma. What ...
Blood Cancer Journal www.nature.com/bcj CURRENT TREATMENT ALGORITHM OPEN Smoldering multiple myeloma current treatment algorithms S. Vincent Rajkumar 1 ✉, Shaji Kumar 1, Sagar Lonial 2 and Maria Victoria Mateos 3 © The Author(s) 2022 Smoldering multiple myeloma (SMM) is an asymptomatic ...
Morgan, G. J.et al. The role of maintenance thalidomide therapy in multiple myeloma: MRC Myeloma IX results and meta-analysis.Blood119, 7–15 (2011). PubMedGoogle Scholar Attal, M.et al. Maintenance treatment with lenalidomide after transplantation for MYELOMA: final analysis of the IFM 2005...