including liver and white adipose tissue. Two isozymes of DGAT, DGAT1 and DGAT2, have been described so far (http://www.uniprot.org/uniprot). Increased DGAT2 activity has a role in steatosis, while
The research group led by Franck Quero at the University of Chile have produced protein-functionalized cellulose fibrils from the tunic ofPyura chilensisby a top-down approach [47]. As illustrated in Fig.3, the CNFs were used to produce films, which were subsequently evaluated as 2D scaffolds ...
the great medical need for a second-line treatment for those that fail sorafenib with advanced stage HCC will continue since a recent press release by Bristol-Myers Squibb (NewYork, NY) 32 Powered by TCPDF (www.tcpdf.org) submit your manuscript | www.dovepress.com Dovepress Hepatic Medicine...
Time management was also discussed in relation to the training required for physiotherapists to use the device. Physiotherapists felt this training had to be multi-faceted to address the complexities of the device, which included: device-specific technical know-how; maintaining patient safety; the n...
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Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer associated with advanced age and immunosuppression. Over the past decade, an association has been discovered between MCC and either integration of the Merkel cell polyomavirus, which likely
in the 1970s,2there has been an exponential evolution accelerated by the epochal FDA approvals of the first immune checkpoint inhibitors (ICIs), the antibody ipilimumab against anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) in 2011 and the first antibodies against anti-programmed cell...
[42]. Among these small molecule inhibitors, several synthetic small molecules from Bristol Myers Squibb (e.g. BMS1166 and BMS202) and Curis Inc. (i.e. CA-170) exhibit promising tumor suppression effects in interrupting the PD-1/PD-L1 interactions [43,44]. However, there are relatively ...
This review aims to consolidate current views on the cells of one of the peripheral nerve sheath layers, perineurium. The relevance of the subject matter owes the lack of basic knowledge about the involvement of these cells in the restoration of damaged nerve conductors, as well as the need ...
The earliest example of a translation of a batch manufacturing process to flow for an aerobic oxidation within the pharmaceutical sector was described by Bristol–Myers Squibb (BMS). BMS researchers were interested in the oxidation of the imide within buspirone to produce 6-hydroxybuspirone (Scheme16...