Some issues remain at the forefront of the controversy involving stem cell research - legislation, ethics and public opinion, cost and concentration methods. As is true with any new technology, the enthusiasm for this technology that has potential to influence virtually every orthopedic case ...
While ESCs have been studied extensively in preclinical models, clinical trials have primarily focused on adult stem cells such as MSCs and NSCs, as well as iPSCs and their derivatives. We critically assess the current state of research for each cell type, highlighting their potential applications ...
Pluripotent stem cells (PSCs) hold great promise for drug discovery and regenerative medicine owing to their ability to differentiate into any cell type in the body. After more than three decades of research, including delays due to the potential tumorigenicity of PSCs and inefficiencies in differe...
Research in human embryonic stem cells (hESCs) is a rapidly developing scientific field. In this study we collect and evaluate a thorough body of data on the current number of publicly disclosed hESC lines and the extent and impact of scientific work involving the use of these cells. These ...
(2) natural antibody activity. Research has proved that tumor-derived IgM recognized many self-antigens (HEp2 cell antigens) and non-self-antigens (single-stranded DNA, double-stranded DNA, and lipopolysaccharide). TLR9 agonists (CpG 2006, CpG 2078, and GpC) stimulated HeLa MR cells to ...
Furthermore, spatial associations indicated a lack of CD8+ T cells in the tumor area where tumor cells lost MHC class I expression [48]. In a pan-cancer analysis involving 33 cancer types, higher expression levels of MHC molecules were significantly associated with favorable survival outcomes and...
Extensive research in this organelle has proven it to have various cellular origins, including stem cells. Its function as an intercellular communicator in diseased and normal cells has been widely accepted [57]. Exosomes habitually differentiated based on the tissue or cell of origin could also be...
With the development of research involving MSCs for the treatment of COVID-19, MSC therapy may be a strategy for responding to the current epidemic. The mechanism of action of MSCs is complex. The key mechanisms include paracrine mechanisms, extracellular vesicles, or direct contact of cells ...
Mesenchymal stem cells (MSCs) are known for being multi-potent. However, they also possess anticancer properties, which has prompted efforts to adapt MSCs for anticancer therapies. However, MSCs have also been widely implicated in pathways that contribute to tumor growth. Numerous studies have been...
Concise review: using stem cells to prevent the progression of myopia-A concept Stem Cells, 33 (2015), pp. 2104-2113 CrossrefView in ScopusGoogle Scholar Kampik, 2012 A. Kampik Pathology of epiretinal membrane, idiopathic macular hole, and vitreomacular traction syndrome Retina, 32 (2012),...