cannabinoid compounds have been successfully tested as a systemic therapeutic option in a number of preclinical models over the past decades. As a result of these efforts, a large body of data suggests that
Moreover, the overexpression of TREK-1 increases the proliferation rate of both NPE and Chinese hamster ovary (CHO) cells, confirming the importance of this channel in the regulation of cell growth. Conversely, the inhibition of TREK-1 activity in cultured cancer cells by a nonspecific blocker ...
Herein two genetic codes from which the primeval RNA code could have originated the standard genetic code (SGC) are derived. One of them, called extended RNA code type I, consists of all codons of the type RNY plus codons obtained by considering the RNA code but in the second (NYR type)...
Cancer therapy has immune checkpoint inhibitors that engage with negative regulators of T-cell activators to rejuvenate the immune system [135] but the rate of response is minimal i.e. 40% due to pre-existing antitumour immune response [137, 138]. For example, a biopsy of melanoma regression...
of V1b causes an increased production of adrenocorticotropic hormone by the adenohypophysis [64]. Finally, V2 stimulation in the kidney increases the exposure of aquaporin 2 at the plasma membrane, which is in turn is responsible for a higher rate of free water reabsorption, plasma dilution, ...
adjustable degradation rate, and good mechanical property of natural and synthetic polymers, vast polymers were used to modify DNA materials for bone regeneration, such as alginate, chitosan, proteins (eg. fibrin, silk, and collagen), glycosaminoglycans, polylactides (PLA), polyglycolides (PGA), ...
“Evidence on the long-term cardiovascular effects of using only e-cigarettes is limited, but acute exposure studies have shown e-cigarettes to have harmful effects on the cardiovascular system, including increased heart rate and blood pressure. More importantly, the use of e-cigaret...
Colorectal cancer is outlined as one of the aggressive cancer types due to its worldwide high incidence and mortality rate. It has been noticed that a particular microRNA, miR-16, exhibited tumor-suppressive characteristics in invasion as well as proliferation; it also mediated the apoptotic proces...
This could be due to the higher rate of consumption of TGF-β1 within the impaired myocardium or due to autocrine and paracrine antifibrotic effects of natriuretic peptides. In a recent study, Ma et al. reported that intermedin 1–53 (IMD1-53) decreased the occurrence of atrial fibrillation...
Since gastric cancer (GC) is diagnosed at advanced stages, the survival rate is low in affected people. In this regard, investigating the mechanisms underlying GC development, are so critical. MiRNAs, which are small non coding RNAs, as a post transcriptional repressor, regulate expression of tar...