Cholangiocarcinoma (CCA) refers to an aggressive malignancy with a high fatality rate and poor prognosis. Globally, the morbidity of CCA is increasing for the past few decades, which has progressed into a disease that gravely endangers human health. Exosomes belong to a class of extracellular vesic...
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Schatz HMcDonald HR Atrophic macular degeneration: rate of spread of geographic atrophyand visual loss. Ophthalmology. 1989;961541- 1551PubMedGoogle ScholarCrossref 236. Weiter JJDelori FDorey CK Central sparing in annular macular degeneration. Am J Ophthalmol. 1988;106286- 292PubMedGoogle Schola...
after co-culturing CLL cells with PMPs, the transfer of the mitochondrial contents and function provided by PMPs induced metabolic reprogramming, leading to an increase in the oxygen consumption rate, ATP levels, and reactive oxygen species production. Further exploration revealed...
For instance, induced myeloperoxidase release and hypochlorite production in neutrophils cause single-walled carbon nanotubes (SWCNT) precoated with HSA to degrade at a greater rate279. 5.3.5. Cytotoxicity PC can increase the safety of nanomedicines against normal cells280, but it can also cause ...
multiple myeloma (r/r MM), with high response rate, low recurrence rate and manageable CRS [43]. Importantly, BCMA-CAR-T immunotherapies Ciltacabtagene-autoleucel and Idecabtagene-vicleucel are now available for the treatment of patients with relapsed and refractory multiple myeloma [44]. ...
Other complications may include Infertility, Osteoporosis, Electrolyte imbalances and dehydration manifesting as increased heart rate, fatigue, weakness and low blood pressure. Because of better quality medical interventions and comprehensive care, there is a remarkable increase in percentage of patients (29....
A study using intrathecal natural IFN-β, showing a potent reduction in relapse rate. This galvanized the development of recombinant IFN-β for MS. CAS PubMed Google Scholar Knobler, R. L. et al. Systemic α-interferon therapy of multiple sclerosis. Neurology 34, 1273–1279 (1984). CAS ...
(2014). I(f) current channel inhibitor (ivabradine) deserves cardioprotective effect via down-regulating the expression of matrix metalloproteinase (MMP)-2 and attenuating apoptosis in diabetic mice. BMC Cardiovasc. Disord. 14:150. doi: 10.1186/1471-2261-1 4-150...
74 Safety, response rate (80%), and survival (15 months) of chemoradiotherapy and then bevacizumab compare favorably with standard treatment for limited SCLC. Randomized studies to assess the role of bevacizumab in improving overall survival in SCLC are being planned. Matrix metalloproteinases (MMPs)...