A study using intrathecal natural IFN-β, showing a potent reduction in relapse rate. This galvanized the development of recombinant IFN-β for MS. CAS PubMed Google Scholar Knobler, R. L. et al. Systemic α-interferon therapy of multiple sclerosis. Neurology 34, 1273–1279 (1984). CAS ...
Like cyclosporine, tacrolimus may be a useful induction agent for severe, corticosteroid-refractory UC, but the long-term colectomy rate remains substantial, so alternative agents need to be considered. pouch-anal anastomosis.26 Pouchitis often presents acutely with abdominal pain, diarrhea, and ...
Polidocanol foam sclerotherapy reported a 79.8% primary closure rate [62]. Surgical Techniques High Ligation and Stripping (HL&S) This surgical technique involves pre-operative DUS marking of saphenofemoral junction (SFJ) for small and precise incision; after the skin incision, the main trunk of...
There is only one known clinical trial that has examined doxycycline use, and it reported that doxycycline can decrease the rate of joint space narrowing in patients with osteoarthritis. Furthermore, doxycycline was well tolerated with minimal side effects reported in both animal and human studies. ...
for a total of 4 cycles. The study found that 15.7% of patients had a partial response, and 36.8% exhibited stable disease, resulting in a disease control rate of 52.6%. These findings suggest that combination therapy could be a promising option for patients with advanced melanoma, especially...
Aging involves the loss and degradation of various physiologic functions in the organism, and these changes are mainly reflected in the loss of cells and constitutive substances in the tissues and slowing down of the metabolic rate. Therefore, maintaining the normal function of mitochondria to ensure...
of CAR-T cells targeting CLDN18.2. Notably, 94.6% of the patients experienced grade 1 or 2 CRS with no serious adverse effects; as for treatment efficacy, the objective response rate (ORR) reached 57.1% and the disease control rate (DCR) was 75%. Moreover, the survival rate at 6 ...
MMP: Matrix metalloproteinase mtDNA: Mitochondrial DNA MVBs: Multivesicular bodies MVs: Microvesicles NCCD: Nomenclature Committee for Cell Death NPC: Nasopharyngeal carcinoma NSCLC: Non-small cell lung cancer OS: Overall survival OSCC: Oral squamous cell carcinoma ...
The 1-year renal survival rate of patients who are double-positive for antineutrophil cytoplasmic antibody (ANCA) and anti-glomerular basement membrane antibody (anti-GBM) with crescentic GN, even after treatment with immunosuppressive drugs and plasma exchange, remains lower than that of patients ...
MMP: Metalloproteinases MoDC: Monocyte-derived dendritic cell NET: Neutrophil extracellular trap NSCLC: Non-small cell lung cancer ORR: Objective response rate OS: Overall survival OVM: Outer membrane vesicle PAMP: Pathogen-associated molecular pattern ...