Non-toxin-producing Bacillus cereus strains belonging to the B. anthracis clade isolated from the International Space Station. Bik H, editor. mSystems. 2017;2:e00021–e00017. van Tongeren SP, Roest HIJ, Degener JE, Harmsen HJM. Bacillus anthracis-like bacteria and other B. cereus group ...
et al. Differential regulation of HCN channel isoform expression in thalamic neurons of epileptic and non-epileptic rat strains. Neurobiol Dis 45, 450–461 (2012). 35. Kanyshkova, T. et al. Postnatal expression pattern of HCN channel isoforms in thalamic neurons: relationship to maturation of ...
In preclinical studies, fludase revealed activity against respiratory viruses, influenza strains, and parainfluenza virus. The entry of HRSV into the cell inhibited by targeting F protein. Antivirals studied that precisely inhibits F-protein are JNJ-53718678, AK-0529, GS-5806, RV521, and BTA-C...
potential use of an mRNA vaccine against the influenza virus. In their work, they designed an mRNA for vaccination the against influenza A virus and showed protection efficacy in mice, ferrets, and domestic pigs. They also suggested that designing mRNA vaccines against the seasonal flu would be ...
progress in clinical studies was stalled because of low mRNA stability, a suboptimal delivery system, and lack of GMP facilities and protocols. Since then, several approaches have been taken to produce mRNA vaccines for influenza that are capable of protecting from different strains of the virus an...
The recombinant vaccine, such as Flublok, contains the HA antigens from seasonal influenza strains produced and purified in insect cells [21]. Flucelavax is an inactivated vaccine that is produced by growing the virus in mammalian cells [22]. The inactivated vaccine remains the popular choice ...
acnes strains are predicted to produce excessive porphyrin, which can cause skin inflammation and contribute to development of acne vulgaris [129]. These findings may perhaps shed light on why certain microbiome-linked skin pathologies are dependent on life stage. In adults, the microbiota of the ...
Owing to the diversity of IBDV strains, it has long been challenging to distinguish between the very virulent classical variation of IBDV (vvIBDV) and the vaccine strain. A single-chain variable fragment that effectively identified the highly conformational epitope of the VP2 protein of vvIBDV ...
Mutation of an RNA virus is a matter of grave concern as it gives rise to newer strains, posing apprehensions that a vaccine developed for one strain might not be effective against a mutated strain. So far, several variants, such as B.1.1.7 (alpha, originated in the UK), B.1.351 (...
Mice lacking the type I IFN receptor, or functional IRFs, are highly sensitive to VEEV infection and show rapid spread, enhanced pathology, failure to clear the virus from circulation, and a shortened mean survival time following infection with virulent, as well as avirulent, strains of VEEV....