Serous borderline ovari- an tumors are characterized by activation of specific tumor suppressor genes (SERPINA5 and dual specificity phosphatase 4 [DUSP4]) that inhibit degradation of the extracellu- lar matrix, a key event in the pathogenesis of invasive growth [16]. Thus, serous bor- der...
Autophagy is a cell survival pathway being also considered a tumor suppressor event that leads to the death of mutated cells [118]. In glioma cells, H2O2 causes autophagic apoptosis following the polycyclic ammonium ion sanguinarine, a treatment that escalates mitochondrial electron leakage and ...
‘event recorder’ system, whereby molecular and phenotypic information of a cell(s) can be obtained at the time of observation with their past event information stored in ‘heritable polymers’ of the same cell. This concept has been demonstrated by many synthetic cellular circuits that monitor ...
The binding of α6β4 to plectin has a central role in hemidesmosome assembly and it is becoming clear that disrupting this interaction is a crucial event in hemidesmosome disassembly. In addition, further insight into the functional interplay between α3β1 and α6β4 has contributed to our ...
adverse event PR: partial response SD: stable disease mPFS: median progression-free survival mOS: median overall survival PSCA: prostate stem cell antigen GPC3: Glypican-3 RTK: Receptor Tyrosine Kinase c-MET: c-mesenchymal-epithelial transition factor ...
Hangao-land,he is keen on his rich color legend about the memory of the countryside.In Zhao's literary imagination of routine countryside,there are much moral thoughts between the hard life and the town-country gap as well as much character fatalism between the soul-stirring event and the ...
Background Most individuals exposed to a traumatic event do not develop post-traumatic stress disorder (PTSD), although many individuals may experience sub... SP Orr,NB Lasko,ML Macklin,... - 《Biology of Mood & Anxiety Disorders》 被引量: 115发表: 2012年 ...
Seer C, Lange F, Georgiev D, Jahanshahi M, Kopp B (2016) Event-related potentials and cognition in Parkinson’s disease: an integrative review. Neurosci Biobehav Rev 71:691–714 Article PubMed Google Scholar Seibert TM, Murphy EA, Kaestner EJ, Brewer JB (2012) Interregional correlations ...
(Supplementary Fig.S2). The comparable oxygen consumption rates between the year 2020 and year 2100 treatment indicates that 10-days before hatch, the embryos in the year 2100 treatment had not yet undergone a mass mortality event (see below). It is important to note that we assumed the 1 ...
As a result, tumors appear to activate an event known as the "angiogenic switch" in order to progress by changing the balance of endogenous angiogenesis inducers and inhibitors more towards a pro-angiogenic outcome and eventually dormant lesion proceed into a malignant phenotype [17]. Angiogenesis ...