In patients with chronic bronchitis a four week trial with inhaled steroids does not attenuate airway inflammation Systemic corticosteroids have been recommended as a therapeutic option in patients with moderate to severe COPD. In an early stage of the disease, i.e. chr... D Loppow,MB Schleiss...
Urinary tract infection (UTI) in children is a major source of office visits and healthcare expenditure. Research into the diagnosis, treatment, and prophy
Although chronic renal failure (CRF) has been found to be associated with a decrease in liver CYP, the mechanism remains poorly understood. The N-demethylation of erythromycin was decreased by more than 35% (P < 0.001) in hepatocytes incubated with serum from rats with CRF221. It is ...
Concerns exist regarding chronic nephrotoxicity with the use of long-term CNI. Continuation of CNIs for more than 2 to 5 years has been shown to be associated with renal toxicity [32,35,36]. In patients with steroid-dependent nephrotic syndrome (SDNS), chronic histologic lesions due to CNI u...
Treatment of complications of Kawasaki disease Cardiovascular complications and treatments Coronary artery disease is the most prominent feature which can further induce CAA, coronary artery stenosis, myocardial infarction, sudden death or even ventricular arrhythmias in KD patients [25]. Chronic use of an...
ABSTRACT:Rheumatoid arthritis (RA) is a chronic connective tissue disease of immunological etiology. In the course of the disease, symptoms of the musculoskeletal system predominate, but other systems can also be affected. The disease may require long-te
[latter approved as an alternative to parenteral hypomethylating agents in myelodysplastic syndrome and chronic myelomonocytic leukemia but commonly used in AML]); and CPX-351 (encapsulated liposomal 5:1 molar ratio of cytarabine and daunorubicin), and glasdegib (hedgehog inhibitor). Other targeted ...
Histone deacetylase inhibitors (HDACi) enhance the cytotoxicity of CD20 CAR-T cells against B-cell malignancies by increasing TNF-α and IFN-γ secretion [164]. This effect is linked to the broad expression of CD20 in non-Hodgkin’s lymphoma, chronic lymphocytic leukemia (CLL), and roughly 40...
Adverse effects associated with topical use of steroids include telangiectasia formation, skin atrophy, striae, hypertrichosis, local super-infection. A rare side effect of topical therapy is hypersensitivity due to systemic absorption of the drug, resulting in side effects compatible with those due to...
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