The lipids were evaluated in terms of antigen-presenting cell (APC) S protein expression levels, with MIC1/MIC2 showing the best performance (Table 2). The superior efficacy of MIC1/MIC2 may stem from their multi-charged nature and higher amine to phosphate ratio, which facilitates efficient...
and move to second lymphoid organs (SLOs), where they cooperate with lymphoid DCs to prime naïve T cells [58,59]. T cell activation begins once they recognize antigen-MHC complexes via T cell receptors, delivering the first signal. For full activation...
Nevertheless, the full application of optogenetics to ATC therapy has yet to be fully realized. CAR-T cells currently dominate the space of optogenetics in adoptive T-cell therapy. There are multiple ways of integrating optical tunability into CAR-T cells and are seen as the model of choice ...
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nanoparticles; MSN, mesoporous silica nanoparticles; PLGA, poly(lactide-co-glycolide); APC, antigen presenting cells Full size image Table 2 Summarize of cancer vaccine adjuvants Full size table Among immunostimulants, Toll-like receptor (TLR) agonists, such as TLR3, TLR4, TLR7/8, and TLR9, ...
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Fe3O4 microparticles, (b, c) stimulation of APC (DC and macrophage) progression, T cells activation, production of pro-inflammatory cytokine and boosting of antitumor response to immunotherapy by reprogramming the TME (corresponding TME modulation in the form of schematic is presented in Fig. (...
rather than the degradation in lysosomes.4Sphingomyelinase catalyzes the conversion of sphingomyelin to ceramide and phosphorylcholine. Ceramide enriched endosomes tend to form inward buds ending in ILV formation Full size image Box 1: Terminology...
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