Chronic hepatitis B virus (HBV) infection is a major global health problem. Current antiviral therapy including pegylated interferon and nucleos(t)ide analogue is effective in reducing progression to cirrhosis, hepatic decompensation, and hepatocellular carcinoma but the rate of HBsAg seroclearance is ...
Hepatitis B is a type of virus that causes serious infection in the liver. If not treated on time, hepatitis B can become chronic leading to permanent scarring or failure of liver function. Most often, hepatitis B can lead to major liver dysfunctions suc
Hepatitis B virus (HBV) is a major cause of acute and chronic liver disease and represents a major public health problem worldwide. Current antiviral therapies with nucleos(t)ide analogues can effectively suppressing viremia but are not curative, and have little or no impact upon the HBV cccDNA...
Hepatitis B virus (HBV) is prevalent worldwide and is difficult to eradicate. Current treatment strategies for chronic hepatitis B ultimately seek to achieve functional cure (FC); however, the factors contributing to FC remain unclear. We aimed to investigate the gut microbiota profiles of patients...
Treatment of chronic hepatitis B virus (HBV) infection with the viral DNA polymerase inhibitors or pegylated alpha-interferon has led to a significant retardation in HBV-related disease progression and reduction in mortality related to chronic hepatitis B associated liver decompensation and hepatocellular ...
Following FDA approval, GigaGen's therapy enters Phase 1 clinical trials as the first recombinant human polyclonal therapy for hepatitis B. Since Contagion's first interview last year with Carter Keller, senior VP at Grifols and head of GigaGen, there has been significant progress in...
Hepatitis B virus (HBV) infection continues to be a major public health issue worldwide. HBsAg loss is associated with functional remission and improved long‐term outcome, and is considered to be a "functional cure" (also referred to as clinical or immunologic cure) for chronic hepatitis B. ...
Keywords: hepatitis B; treatment; cure; target 1. Introduction Hepatitis B virus (HBV) infection is a leading cause of chronic liver disease worldwide. Antiviral agents, such as interferon and nucleos(t)ide analogues (NAs), have been used to treat patients with chronic hepatitis B (CHB). ...
Case in point: The recent discovery of a biomarker that can predict if an individual will achieve a functional cure of hepatitis B virus (HBV) gave rise to a surge of interest from the pharmaceutical industry in researching curative therapies for HBV. ...
Interferon-free cure of hepatitis C virus infection does alter the soluble inflammatory milieu which could affect hepatocellular carcinoma surveillance by CD8+ T cells in patients with liver cirrhosis SO Sekyere,C Falk,A Aregay,... - 《Journal of Hepatology》...