Long standing duct obstruction and ductal pressure caused by pancreatic fibrosis are considered responsible for activating signaling pathways promoting cellular transformation [205]. Although ductal pancreatic tumors and ductal preneoplastic lesion cells have long been thought to originate exclusively from pancr...
WHIM syndrome is a rare combined primary immunodeficiency disease named by acronym for the diagnostic tetrad of warts, hypogammaglobulinemia, infections, and myelokathexis. Myelokathexis is a unique form of non-cyclic severe congenital neutropenia caused by accumulation of mature and degenerating neut...