Renal failure is a major health problem. The mortality rate remain high despite of several therapies. The most complex of the renal issues are solved through stem cells. In this review, different mechanism for cure of chronic kidney injury along with cell engraftment incorporated into renal structu...
Although kidney transplantation is a viable therapeutic option, this thera... T Thatava,AS Armstrong… - 《Stem Cell Research & Therapy》 被引量: 77发表: 2011年 Pkd1-inactivation in vascular smooth muscle cells and adaptation to hypertension. Autosomal dominant polycystic kidney disease (ADPKD) ...
This image, produced by a fluorescence microscope, shows a normal renal proximal tubule, the specific nephron segment in the kidney that is impaired in the rare disease infantile cystinosis. The red, green and yellow regions indicate the presence of different proteins in the tubule and the blue...
And as these children develop, they often require long-term, intensive therapy to prevent further deterioration and loss of kidney function. There is no cure. But there could be. Maybe there should be. In 2002, while working with a collaborator at Harvard University, we injected embryonic ...
In order to deliver their lab-grown islet to diabetics, Semma is developing prototypes of an iPhone-sized, retrievable packet whose materials insulate it from the immune system, so that patients don’t have to take immune-suppressing drugs, as they would if they had a kidney transplant. Chr...
Over years, excess sugar in the bloodstream damages blood vessels and organs. Without effective treatment, diabetics suffer severe complications: blindness, kidney failure, heart disease, amputations, even premature death. On the other hand, too much insulin can cause very low blood sugar, w...
InsulinreplacementtherapyistheonlytreatmentofType1,andcannot preventmanyofthesideeffects,fromheartattackstokidneyfailure. InType1diabetes,thepancreasdoesnotproduceenoughinsulintoshift glucoseintothecellsthatneedit.InType2diabetes,theinsulinthatis producedisnotusedeffectively--somethingcalledinsulinresistance--also ...
" Rhee said. In chelation therapy, drugs reduce excess levels of metals in the body to prevent toxicity. "Chelation therapy is, unfortunately, toxic to the kidneys," Rhee said. "Angelina's liver disease had also caused kidney failure, so the chelation therapy wasn't a safe option. That ...
So goodbye to allopurinol (kidney protection) and fluconozole (to ward off potential fungal infections which can be a risk after CAR-T) and back up to 3 tablets a day for ibrutinib from tomorrow. It means I’m now only on that and Bactrim (a protective antibiotic), vacyclivir (to war...
precedes the development of beta cell expansion during pregnancy and it has been demonstrated that human pancreatic progenitor cells differentiate into islets. Similarly, patients who have been on long term immunosuppression for kidney transplantation have been observed to regenerate insulin producing islets...