Vault nanoparticles show promise for cancer treatment and possible HIV cureUCLAAcs Nano
Researchers at Washington University packaged low doses of titanocene inside nanoparticles they targeted to proteins known to sit on the surface of cancer cells, and found that when the nanoparticles make contact with cancer cells, their membranes fuse together, releasing the titanocene into the ce...
Further, in prostate cancer, lipid coated PLGA nanoparticle was used with luciferase siRNA showed in vitro knock down of genes [76]. Another formulation was developed of PLGA-PEI nanoparticles using double emulsion-solvent evaporation technique, using luciferase as the oligonucleotide for silencing. ...
Antigen-specific immunotherapies (ASITs) for T1D range from peptides, proteins, gene transfer, nanoparticles, cell therapies, or biomimicry of naturally occurring tolerogenic processes. These strategies offer several advantages, particularly their potential to target the underlying autoimmune responses without...
Immune checkpoint pathways have been studied extensively in cancer research as they limit the threshold for T cell activation and duration of immune responses (Sharpe, 2017). Blockade of immune checkpoint pathways, either at the target cell or the effector cell, prevents inhibitory signaling and was...
Despite the success of antiretroviral therapy (ART) for people living with HIV, lifelong treatment is required and there is no cure. HIV can integrate in the host genome and persist for the life span of the infected cell. These latently infected cells are not recognized as foreign because they...
[54]. Celgene has a portfolio of albumin-based nanoparticles for cancer treatment, which have been presented in a report by Desai [94]. In this report, preclinical studies of ABI-008 and ABI-009 are described. ABI-008 contains the active drug docetaxel. It has completed phase I/II [95]...
Improving tumor treatment through intratumoral injection of drug-loaded magnetic nanoparticles and low-intensity ultrasound Article Open access 16 January 2024 Introduction Glioblastoma multiforme (GBM) is a highly aggressive and deeply penetrating brain cancer that is notoriously difficult to treat1,2,3,...
Worldwide, an estimated 296 million people are living with chronic hepatitis B virus (HBV) infection, with a significant risk of morbidity and mortality. C
According to yet another embodiment, the pharmaceutical composition comprising as an active ingredient the antibody of the invention is preferably used for the treatment of cancer. According to yet another embodiment, the pharmaceutical composition may be administered either following detection of primary ...