for the samples are known to high accuracy.Lead author Dr Gonzalo Vallejo-Fernandez, from York's Department of Physics, said: While clinical trials have shown the potential of magnetic nanoparticles for cancer treatment, the mechanisms by which the heat is generated have not been fully understood...
Researchers at Washington University packaged low doses of titanocene inside nanoparticles they targeted to proteins known to sit on the surface of cancer cells, and found that when the nanoparticles make contact with cancer cells, their membranes fuse together, releasing the titanocene into the ce...
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In addition to albumin-based nanoparticle therapeutics, diagnostic nanoparticles have been developed.99mTc-Albures and99mTc-Nanocoll are both albumin aggregated particles containing the metastable nuclear isotope of technetium-99 that have been used for various diagnostics purposes in cancer and infectious di...
1). Targeting epigenetic modulators is a promising approach that has already been developed and approved for cancer treatment and has been investigated against HIV and Epstein-Barr virus (EBV) infections [58, 59]. The cccDNA is organized as a minichromosome with histone and non-histone proteins ...
Despite the success of antiretroviral therapy (ART) for people living with HIV, lifelong treatment is required and there is no cure. HIV can integrate in the host genome and persist for the life span of the infected cell. These latently infected cells are not recognized as foreign because they...
We have previously shown that non-toxic, biodegradable PAA based NPs are suitable delivery vehicles for cancer-imaging and/or phototherapy agents to the tumor46,47,48,49. Additionally, we established that the NPs had a photo-triggered release mechanism of the payload when exposed to at least 2...
Nanoparticles for the delivery of therapeutic antibodies: dogma or promising strategy? Expet Opin. Drug Deliv., 14 (2017), pp. 1163-1176 CrossrefView in ScopusGoogle Scholar Spivak and Planelles, 2016 A.M. Spivak, V. Planelles HIV-1 eradication: early trials (and tribulations) Trends Mol. ...
CRISPR/Cas: Advances, Limitations, and Applications for Precision Cancer Research. Front. Med. 2021, 8, 649896. [Google Scholar] [CrossRef] Fu, Y.; Foden, J.A.; Khayter, C.; Maeder, M.L.; Reyon, D.; Joung, J.K.; Sander, J.D. High-frequency off-target mutagenesis induced by...
Targeting ICBs and blocking them is increasingly being considered for therapeutic purposes in cancer and other diseases. There is the hope that ICBs might partially reverse HIV-associated immune dysfunction, enhance immune effector functions and HIV-specific CD4+ and CD8+ T cell responses in blood an...