Ramasamy TS, Ayob AZ, Myint HH, et al. Targeting colorectal cancer stem cells using curcumin and curcumin analogues: insights into the mechanism of the therapeutic efficacy.Cancer Cell Int.2015;15:96. Sreedhar R, Arumugam S, Thandavarayan RA, et al. Curcumin as a therapeutic agent in the...
Network pharmacology and bioinformatics approach reveals the therapeutic mechanism of action of curcumin in Alzheimer disease 来自 EBSCO 喜欢 0 阅读量: 47 作者:D Vijh,MA Imam,MMU Haque,S Das,A Islam,MZ Malik 摘要: Curcumin is a natural anti-inflammatory and antioxidant substance which plays a ...
Curcumin blocked NF-κB signaling through the inhibition of nuclear translocation of NF-κB p50 subunit. Curcumin also attenuated DNA binding activity of p50 and p65 subunits and suppressed STAT1 phosphorylation. Although further study is required to explore the detailed mechanism of action, curcumin ...
In the present study, the effect and possible mechanism of demethoxycurcumin on the production of pro-inflammatory mediators in LPS-activated N9 microglial cells were further investigated. The results showed that demethoxycurcumin significantly suppressed the NO production induced by LPS in N9 microglial...
In addition it would support the proposed mechanism of action by Curcumin acting through the same pathway. Scientific Reports | 6:24675 | DOI: 10.1038/srep24675 6 www.nature.com/scientificreports/ Figure 4. Effect of Curcumin on constitutive and OXA-induced NF-κB activation. (a) Western ...
Curcumin: Potential Health Benefits, Molecular Mechanism of Action, and Its Anticancer Properties In Vitro and In Vivo The nutraceutical curcumin is a polyphenolic yellow pigment found in turmeric, the ground form of the Curcuma longa species. The interest that the medical world has shown towards th...
Study systemDose Empty CellTime of administrationRoute of administrationMechanism of actionReferences In vitro study Human Huh-7 cells 10–20 µM Pre- transfection NA Activates lysosomal destabilization, induces apoptosis Oyanguren et al., 2020 HeLa, BHK-21, and Vero-E6 cells 5 µM Pre-transfe...
Funk JL, Frye JB, Oyarzo JN, Kuscuoglu N, Wilson J, McCaffrey G, et al. Efficacy and mechanism of action of turmeric supplements in the treatment of experimental arthritis. Arthritis Rheum. 2006 Nov;54(11):3452-64. Gautam SC, Gao X, Dulchavsky S. Immunodilation by curcumin. Adv Exp...
The functional application and therapeutic potential of curcumin in the treatment of aging-associated diseases is well documented in the literature. This review article focuses mainly on the potential role of plant-derived natural compounds such as curcumin, their mechanism of action and recent advances...
[21]. Moreover, the increase in total proteins, globulin and albumin may be associated with the enhanced innate immune response mechanism of fish as represented by high lysozyme activity results [59]. In the present study, the increase in WBCs, monocyte percentage, phagocytic activity and ...