This is what I see when slicing for BIBO2 dual (as distributed with Cura), all extruders are set to Not overridden with the model assigned to E2, no supports, no prime tower, Normal 25% infill profile, my materials Sunlu White PLA and Green Silk PLA assigned to E1 and E2, respectively...
We'd be happy to add profiles for Silk or PLA+ for your printer! However since I don't have your printer nor your material, I can't create those profiles. I don't know what settings make it print well. I have a Ender 3 v2 and the PLA+ and Silk are eSun Collaborator Ghostkeeper...