Melatonin and steroid hormones are cytochrome P450 (CYP or P450; EC 1.14.14.1) substrates that have antioxidant properties and mitochondrial protective activities. The mitochondrial intermembrane space (IMS) Cu,Zn-superoxide dismutase (SOD1) is activated after oxidative modification of its critical thiol...
Melatonin and steroid hormones activate Cu,Zn-superoxide dismutase by means of mitochon- drial cytochrome P450. Free Radic. Biol. Med. 50, 1575-1581.Pedro Iñarrea,Alvaro Casanova,Maria Angeles Alava,María Iturralde,Enrique Cadenas.Melatonin and steroid hormones activate intermembrane Cu,Zn-...
目的研究细胞色素P450(cytochrome P450)1B1基因SNP rs1056836在宁夏地区正常汉族人群中的基因型频率、等位基因频率分布特征。方法应用等位基因特异性扩增(AS-PCR)及DNA测序法对410名宁夏汉族正常成人CYP1B1rs1056836C→G位点基因多态性的分布进行测定,并应用χ2检验比较宁夏汉族人群与我国其他地区汉族人群基因频率的分布...
Probing the struc- ture of the linker connecting the reductase and heme domains of cytochrome P450BM-3 using site-directed mutagenesis [ J ]. Protein Science, 1996,5 (7) : 1389 - 1393.Govindaraj S,Poulos T L.Probing the structure of the linker connecting the reductase and heme domains ...
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1.本外观设计产品的名称:保温瓶(DA1000);2.本外观设计产品的用途:适合于家庭,饭店等用于保温食物;3.本外观设计的设计要点:设计要点在于形状;4.本外观设计产品的后视图与主视图对称,省略后视图;5.最能表明设计要点的图片或者照片:立体图. 陈建平 被引量: 0发表: 2011年 "一月风暴"保温瓶 自从一代文豪巴金老人...
CONSTITUTION: A agent for inhibiting the activity of cytochrome P450 enzyme and NADPH-cytochrome P450 reductase contains cupric ion to inhibit the activity at a protein level. Only the cupric ion of divalent cation metals containing Ca, Cu, Co, Mg, Mn, Zn or the like inhibits a P450 system...
对于亚健康状态,其在当前是威胁人们生命健康安全的重要问题,随着我国经济的快速发展,人们的生活压力逐渐增加,使得该疾病的发生率逐年上升,亚健康疾病的防治工作已经成为我国当前的重要医疗任务."治未病"作为我国中医预防学中的重要组成内容,其通过内养外防的方法对人们的精神和生理状态进行调整,实现神形合一,这是人与...
The most abundantly expressed renal UGTs are 1A9 and 2B7, which play a significant role in the glucuronidation of drugs, arachidonic acid, prostaglandins, leukotrienes and P450 derived arachidonic acid metabolites. Modulation by drug substrates (e.g. NSAIDs) of the intrarenal activity of UGT1A9 ...
Cume hydroperoxide impr oxidant for in vitro Cyp2D6 Cyp3A4 P450 turnoverAuclair, K