Results: Fifty-one CTX-M positive isolates were identified. There was no resistance to phosphomycin. The ISEcp1, IS26a, and IS26b were detected in upstream of 84.3%, 5.8% and 9.8% of CTX-M, respectively. The orf477 was detected downstream of all CTX-M positive isolates. Thirty-six ...
pneumoniae isolates exhibiting extended spectrum β-lactam resist- ance, there was a high prevalence of blaSHV and blaCTX-M genes. This result highlights the need for a reliable epidemio- logical apparatus that involves the molecular characterisation of ESBL resistance. Keywords: Extended-...
inhibitors of β-lactamases can combat this resistance, and the β-lactamase inhibitory protein (BLIP) is a naturally occurring inhibitor. The widespread CTX-M-14 and CTX-M-15 β-lactamases have an 83% sequence identity. In this study, we show that BLIP weakly inhibits CTX-M-14 but potentl...
The horizontal spread of blaCTX-M genes among strains of the same or different enterobacterial species is largely promoted by plasmids, which often are self-conjugative and carry additional resistance determinants [4]. FUNCTIONAL PROPERTIES OF CTX-M-TYPE β-LACTAMASES The CTX-M-type β-lactamases...
The growing burden of antimicrobial resistance. Examples of this are the international pandemic of different genotypes of CTX-M extended-spectrum beta-lactamases (particularly CTX-M-14 and -15) and the... PM Hawkey - 《Journal of Antimicrobial Chemotherapy》 被引量: 535发表: 2008年 Spread of ...
The results of susceptibility testing demonstrated two enzymes were highly activity against broad spectrum β-lactams, but the level of resistance was reduced with the addition of β-lactamase inhibitors. The bla CTX-M-80 gene was detected on a 110-kb plasmid and the bla CTX-M-81 gene ...
据有关报道,CTX-M型和TEM型或SHV型的同源性较低,仅为40%[2]。目前发现的的CTX-M型ESBLs种类超过107种,根据其氨基酸序列的差异(大于94%的相同序列认为是一个群,小于90%的相同序列认为是不同的群)分为5个群[3]:CTX-M-1 群包括 CTX-M-1、CTX-M-3、CTX-M-10、CTX-M-12、CTX-M-15、FEC-1、...
Humans Klebsiella pneumoniae Klebsiella Infections beta-Lactamases Drug Resistance, Multiple, Bacterial Genotype Hospitals Gene Expression Regulation, Bacterial Gene Expression Regulation, Enzymologic Cross Infection DOI: 10.1016/S0161-5890(02)00005-6 被...
The blaNDM-1 gene was flanked by genetic elements that are distinct from those observed in other blaNDM-1-positive plasmids, including the groES and groEL chaperonin genes. This plasmid harboured the ESBL gene blaCTX-M-15 together with the quinolone resistance gene qnrB1. In addition, it ...
12.Distribution and Property of Resistance of CTX-M-Type ESBLs-producing Escherichia Coli Isolated from Bengbu Area;蚌埠地区产CTX-M型超广谱β-内酰胺酶大肠埃希菌的分布与耐药特征 13.Cloning and expression of CTX-M-38 β-lactamase geneCTX-M-38型β-内酰胺酶的克隆与表达 14.CTX-M-38,a novel ...