The present invention relates to a CTLA4-Ig fusion protein, in which an extracellular region of the CTLA4 is connected to CH2, CH3, and CH4 of IgM or to hinge, CH2 and CH3 of IgG1 Cys308, and six monomers of which are polymerized to be a hexameric structure. According to the present...
CTLA4是维持体内免疫稳态的负调控因子,对该分子的研究有助于阐明许多重要的免疫机制。目前研究表明,CTLA4-IgG和CTLA4-IgM分子能抑制免疫排斥反应,使机体形成耐受,这不仅为临床组织和器官的移植提供了新的治疗方案,而且有望成为解决基因治疗中细胞表达被排斥这难题的辅助药物〔8,9〕。另外,抗CTLA4抗体还能够有效地用于...
A fusion protein, CTLA4-Ig, consisting of the extracellular domain of CTLA4 in combination with the constant region of the human immunoglobulin Cy chain, has been developed to investigate the effects of inhibition of the B7/CD28 costimulatory pathway on transplant rejection. CTLA4-Ig acts as a co...
ciatedantigen4Igfusionprotein(CTLA4一Ig) inratallografthepatocytetransplantationmodelandthe mechanisms.Methods Acuteliverfailure(ALF)modelwasestablishedbyintraperitonealinjectionof 10%D—galsolutiontoSDrates.CollagenaseperfusionwasperformedonSDratstoseparatelivercells.SD ...
THU0542 In Vitro Anti-Inflammatory Effects of Dexamethasone and Ctla4-Ig (ABATACEPT) Combined TreatmentBackground In rheumatoid arthritis (RA) the combination of glucocorticoids (GC) and the fusion protein CTLA4-Ig (abatacept) allows to obtain better clinical improvement than CTLA4-Ig monotherapy. ...
While the key function of endogenous Treg CTLA4 in trans-endocytosis of costimulation [31] is not replicated by CTLA4-Ig, the fusion protein competitively binds CD80/CD86, repressing CD28 costimulation in T cells [3, 15, 16]. In addition to its widespread usage in common autoimmune conditions,...
一IRES—OX40暖containedbothofthefusionproteinCTLA4IgandOX40Ig.TheresuItsofMLR demonstratedthattransfectionofAdCTLA4lg—IRES—OX40lgwascapableofinhibitingxenogeneicMLR by a way that much stronger than that of Ad CT LA4 Ig and Ad OX4 0 Ig alone .A greater in vitro MLR inhibition ...
A fusion protein, CTLA4-Ig, consisting of the extracellular domain of CTLA4 in combination with the constant region of the human immunoglobulin Cy chain, has been developed to investigate the effects of inhibition of the B7/CD28 costimulatory pathway on transplant rejection. CTLA4-Ig acts as a ...
Prolongation of renal allograft survival with blockade of the CD28 pathway using a novel mutant CTLA4-Ig fusion protein in non-human primates 来自 Semantic Scholar 喜欢 0 阅读量: 45 作者:Pearson,C Thomas,Lin,Angello,Odom,Kris,Cowan,Shannon,Robert ...
The fusion of CTLA4 with an Ig Fc region is referred to herein as a CTLA4-Ig or CTLA4-Ig protein.CTLA4 VariantsThe target binding portion or fusion partner of the immunoadhesins of the invention are comprised of the protein CTLA4. Thus the immunoadhesins of the invention are directed to ...