高达 60% 的 CTD 患者有亚临床 ILD 的证据,关于这些变化随时间进展的数据有限,并未建立起亚临床 CTD-ILD 治疗指南。疾病进展可能发生在亚临床 CTD-ILD 的任何时间点,在 SSc 中数据表明大部分患者进行性进展为诊断 SSc 后的 2～5 年内;各种 CTD 中启动 ILD 特异性治疗的决定很复杂,通常仅用于有呼吸道症状、...
In 2020, advances in the treatment of CTD-associated ILD have included the re-evaluation of methotrexate-induced lung injury and emerging insights on anti-IL-6 therapy and anti-fibrotic therapy in this condition. Key advances Methotrexate use is probably not a notable cause of chronic fibrotic ...
The treatment of CTD-ILD requires immunosuppression with either steroid or steroid-sparing agents. Lung transplantation may be an option for those with end-stage lung disease. Issues to consider Patients with CTD-ILD often present with poor quality of life; however, therapy is also associated with...
而具有自身免疫特征的间质性肺炎(IPAF)为一组异质性的ILD类型,即患者具有潜在的自身免疫病特征但又不符合各类CTD的分类标准[1],其临床特征、诊疗预后与CTD-ILD有很大重叠,部分甚至是CTD-ILD的早期或诊断前期。 图片来源:站酷海洛 在CTD-I...
该名患者自2021年2月-2022年3月在我院历经6次肺穿刺活检术,对两肺新发结节穿刺后病理回报都为肉芽肿性炎,经呼吸科及风湿科联合会诊后诊断CTD 抗JO-1抗体综合征,虽然CTD诊断明确,但患者没有典型的临床症状表现,而且合并出现孤立性肺结节在临床少见,仅有一些肺系疾病的症状如咳嗽咳痰表现出来,为肌炎相关性ILD。
Oliver Distler and Prof. Toby Maher will review the importance of timely treatment, the management practices and treatment guidelines for CTD-ILD.Oliver DistlerSwitzerlandToby MaherUnited KingdomWorld Scientific Publishing CompanyJournal of Clinical Rheumatology and Immunology...
结果与结论：IPAF为一类具有CTD-ILD疾病特征，根据国内外研究分析，及临床分析，我们发现在一些诊断为特发性肺间质纤维化的患者中，并非单纯的ITP，在很多方面具有ITP没有的特征，但是又无法诊断为风湿免疫性疾病。并且认识到它介于特发性间质性肺病与结缔组织疾病相关间质性肺病中间，可能为CTD前期，可能较CTD-ILD...
As previously mentioned, a multidisciplinary approach to the diagnosis and treatment of connective tissue disease-associated interstitial lung disease (CTD-ILD) is of paramount importance. A thorough history and physical examination should be supplemented by chest radiography, serum biomarkers and, occasiona...
If indicated, treatment of the CTD-ILD is largely with immunomodulation, with the aim to prevent progression of the ILD before further irreversible lung injury and disability occurs. Corticosteroids, cyclophosphamide, mycophenolate mofetil and azathioprine are the most common immunosuppressive agents ...
(CTD-ILD)234例(28.9%),具有自身免疫特征的间质性肺炎(IPAF)147例(18.1%),其他原因16例(2.0%).CTD-ILD中,最常见的为皮肌炎相关性ILD(71例,30.4%)和类... 赵稳,汪延生,余治奇,... - 《临床内科杂志》 被引量: 0发表: 2020年 IPAF should receive early treatment for sharing similar clinical charact...