The authors stated that the main drawback of this review was the heterogeneity of metrics in the 11 studies. Unfortunately, it was difficult to evaluate if any particular variable, such as biopsy method or specimen transfer and processing method, had a statistically significant effect on diagnostic...
On the other hand, the results of randomized trials with a fractional flow reserve (FFR)-guided coronary intervention (DEFER, FAME I, FAME II) showed that it is not the angiographically determined morphological severity of CAD but the functional severity determined by FFR that is critical for p...