PD-L1作为一种t细胞免疫检查点分子,可以灭活表达细胞表面PD-1(也称为CD279)的肿瘤浸润淋巴细胞(TILs)。PD-L1和PD-1之间的相互作用导致幼稚的CD4+T细胞分化为调节性t淋巴细胞(tregs),从而抑制免疫激活和效应反应。破坏PD-1/PD-L1轴...
小檗碱通过抑制非小细胞肺癌中COP9信号转导体5(CSN5)的脱泛素活性,减少细胞程序性死亡配体1(PD-L1)的表达,促进抗肿瘤免疫.该项成果由中国医学科学院北京协和医学院生物技术研究所刘洋团队完成,发表在《Acta Pharmaceutica Sinica B》杂志上.程序性细胞死亡-1(PD-1)/PD-L1阻断疗法已成为癌症免疫疗法的一个主要...
一些靶向PD-1/PD-L1免疫检查点的抗体获得临床批准,并显示出了很好的临床活性,相对来说,小分子免疫检查点阻断剂因其在药代动力学特性、组织和肿瘤渗透性、以及生产成本等方面的天然优势,具有广阔的应用前景。到目前为止,仍没有靶向PD-1/PD-L1的小分子抑制剂上市用于临床治疗。我们对天然产物来源的活性小分子化合物...
TNF-α CSN5 PD-L1 Significance Chronic inflammation in cancer is often associated with disease aggressiveness. In the current study of inflammation-mediated immune response in cancer, we report the TNF-α/p65/CSN5/PD-L1 signaling axis as a deubiquitination mechanism stabilizing cancer cell PD-L1 ...
Macrophage-derived CCL5 facilitates immune escape of colorectal cancer cells via the p65/STAT3-CSN5-PD-L1 pathway Chao Liu, Zhaoying Yao, Jianing Wang, Wen Zhang, Yan Yang, Yan Zhang, Xinliang Qu, Yubing Zhu, Jianjun Zou, Sishi Peng, Yan Zhao, Shuli Zhao, Bangshun He...
CSN5-IN-1-DataSheet-MCE CSN5-IN-1 (compound Ac-11) 是 CSN5 的抑制剂，经过 FP 试验和荧光试验分别测得 IC50 为 12.56 μM 和 19 μM。CSN5-IN-1 还可以下调细胞中 PD-L1 的表达，上调 NEDD8-Cul1 的表达。[1]. Discovering New Metallo-Deubiquitinase CSN5 Inhibitors by a Non-Catalytic ...
Shikonin blocked immune evasion in PC, and lowered the expression of PD-L1, NF-κB, NF-κB p65, STAT3 and CSN5 in vivo and in vitro. Conclusion The findings indicated Shikonin inhibited immune evasion in PC by inhibiting PD-L1 glycosylation and activating the NF-κB/STAT3 and NF-κB/CS...
PS1306 JAB1/CSN5 STABILIZES PD-L1 PROTEIN AND CORRELATES WITH STAT3 ACTIVATION IN T-CELL LYMPHOMASdoi:10.1097/01.HS9.0000563504.61860.73Drakos, E.Neves da Silva, P. FarrajotaKokaraki, G.Stathopoulou, K.Atsaves, V.Medeiros, L.J.sterborg, A....
Our results suggest that the novel CCL5-p65/STAT3-CSN5-PD-L1 signaling axis is significantly activated by LPS or HCD-driven macrophage infiltration in an animal model of CRC, which likely has therapeutic and prognostic implications for human cancers.Liu, Chao...
Additionally, PDIA6 overexpression promoted deubiquitination of 尾-catenin and PD-L1 and subsequently upregulated their expression in PC cells. These alterations were partly reversed by CSN5 shRNA. Collectively, the above results demonstrate that PDIA6 contributes to PC progression, which may be ...