The CSHL research found that the three genes termed TTF1, NKX2-8, and PAX9 interact to reactivate what appears to be an early fetal gene expression pattern that results in cancer tumor growth. “The collaboration of these genes and the fact that they are so close together on the chromosome...
Human lymphoblastoid cells derived from different healthy individualsdisplay considerable variation in their transcription profiles.Here we show that such variation in gene expression underliesinterindividual susceptibility to DNA damaging agents. The resultsdemonstrate the massive differences in sensitivity across ...
Scientists at Cold Spring Harbor Laboratory have taken the search for cancer-causing genes an important step forward. In a newly published paper, they confirm that a gene called DLC1 is a tumor suppressor. They have demonstrated in living mice that its deletion, inactivation or loss precipitates...
Toolkit for QC, gene/junction counting, and other miscellaneous downstream processing from RNA-seq alignments. Software: https://github.com/hartleys/QoRTs Paper: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506620/ JunctionSeq: R package for testing differential junction usage with RNA-seq data...
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Pull requests Actions Projects Security Insights Additional navigation options master 1Branch0Tags Code Folders and files Name Last commit message Last commit date Latest commit rhassett-cshl Update documentation with roxygen2 7.3.2 Jul 19, 2024 ...
The research group of Professor Gingeras at Cold Spring Harbor Laboratory investigates the storage of functional information within genomes, crucial for understanding how gene mutations impact biological and clinical outcomes in humans and other organisms. His leadership in large-scale projects like ENCODE...
Without usingfactor, the x-labe will not be properly displayed. Relative Distance Relative distance is somehow wrong. The concept of relative distance will treat the first exon of short gene as same as the exon of long gene. However, their distances to their polyA site are distinct....
('BUM');ForEMBL,Swissprot,GenbankformatsSequencedatabases•RepresentSequences,Features,Annotations•Denormalizerelationships•Allowefficientqueriesfor•“AllexonsinspeciesX”•“AllgeneswithdescriptionY”•“LongestmRNAfromeachgene”Featuredatabases•BioPerldatabases•Bio::DB::GFF•Bio::DB::...
近日,bioRxiv刊登了一篇关于更快速更精确检测融合基因的新工具的文章,文章来自哈佛-麻省理工学院Broad Institute的Brian J. Haas和冷泉港实验室(CSHL)的Alex Dobin等人。他们将这一新开发的工具命名为STAR-Fusion。 STAR-Fusion可从RNA-seq数据中快速并精确地检测出融合基因,检测流程分为三步:一是利用STAR软件将测序...