The AFS98 monoclonal antibody reacts with mouse colony stimulating factor 1 receptor (CSF1R), also known as macrophage colony-stimulating factor receptor (M-CSFR), and CD115. CSF1R is a single-pass type I membrane protein and member of the platelet-derived growth factor receptor family. In m...
Clone AFS98 Target CD115 Formats AvailableView All Product Type Monoclonal Antibody Alternate Names Macrophage Colony Stimulating Factor Receptor, M-CSFR, CSF-R1, C-fms, CSF-1R Isotype Rat IgG2a κ Applications B , CyTOF® , Depletion , FA , FC , in vivoSelect...
(2011). “Coordinate regulation of tissue macrophage and dendritic cell population dynamics by CSF-1.” J Exp Med 208(9): 1901-1916 in vivo macrophage depletion Lim, A. K., et al. (2009). “Antibody blockade of c-fms sup...
CSF1 signaling is also required for maintenance of the macrophage populations in adult mice. Treatment of adult mice with a blocking anti-CSF1R antibody produces an almost complete depletion of tissue macrophage populations in most organs, including the intestinal lamina propria6. Conversely, treatment...
in vivo macrophage depletion* in vitro CSF1R neutralization* in vivo monocyte depletion* Flow cytometry* Western blot* *Reported for the original rat IgG2a AFS98 antibody 产品形式 PBS, pH 7.0,Contains no stabilizers or preservatives 纯度
(2011). “Coordinate regulation of tissue macrophage and dendritic cell population dynamics by CSF-1.” J Exp Med 208(9): 1901-1916 in vivo macrophage depletion Lim, A. K., et al. (2009). “Antibody blockade of c-fms suppresses the progression of inflammation and injury in early ...
Previously, patients with advanced metastatic disease have been treated with Emactuzumab, an antibody targeting the colony stimulating factor-1 cytokine receptor. Although treatment resulted in a strong reduction of tumor-associated macrophages in the vast majority of patients, the individual degree of ...
(PBS-T) for 1 h at room temperature to block non-specific binding sites. Anti-Iba1 primary antibody (1:1000; rabbit; Synaptic Systems) was diluted in PBS-T and applied on sections overnight at room temperature in a humidified chamber. Labeling was visualized using Alexa Fluor secondary ...
RNA-Seq was used to address the pathways affected by macrophage depletion in islets. In accordance with a study using the CSF1R antibody AFS98 [29], macrophage markers and macrophage-related pathways were down- regulated. Thereby, several mediators of cytokine activ- ity were reduced in islets ...
Parkinson’s disease (PD) is a neurodegenerative disorder that is characterized by the presence of proteinaceous alpha-synuclein (α-syn) inclusions (Lewy bodies), markers of neuroinflammation and the progressive loss of nigrostriatal dopamine (DA) neuro