This biomarker profile is concordant with amyloid PET imaging, and either can be used to enable access to AD-modifying therapies. We report findings of the National Dementia Diagnostics Laboratory (NDDL) in AD biomarker testing in community settings. We also discuss the utility of AD biomarkers ...
Prospectively recruited patients were classified based on clinical presentation and the core CSF biomarker profile (amyloid‐beta[Aβ1 60 pg/ml) measured by INNOTEST immunoassays (Fujirebio). Diagnostic performance was compared against INNOTEST p‐tau181 using area under the curve (AUC). The in﹉...
摘要: Test for the presence of protein 14-3-3 in the CSF of patients with suspected sCJD has been used for many years but has been in debate recently. Lumbar puncture is routinely done for CSF analysis of 14-3-3 by neurologists in suspected case of CJD...收藏...
To evaluate the usefulness of clinical examinations in the diagnosis of CJD, we examined duration between initial manifestation of CJD and detection of PSD, specific findings on MRI, 14-3-3 protein, or high NSE. We analyzed data collected by Japanese CJD surveillance committee statistically. Patien...
as well as the inflammatory protein SERPINA3. The Nf+A+ individuals show patterns of a broader neurodegeneration and could thus be expected to show an altered protein profile compared to the other individuals. Stratification based on CSF Aβ42/Aβ40 ratio andAPOEε4 carrier status did only di...
Editors select a small number of articles recently published in the journal that they believe will be particularly interesting to readers, or important in the respective research area. The aim is to provide a snapshot of some of the most exciting work published in the various research areas of...