This chapter discusses the data (mainly IgG) expression in relation to other proteins such as, albumin, the comparatively wide range of normal variability for CSF protein levels, and points of possible discrepancy in dealing with normal versus abnormal values for IgG. Furthermore, it focuses on ...
CSF IgG index and a comparison of oligoclonal bands in the CSF and blood did not reveal evidence for intrathecal immunoglobulin production. In the CSF, tumor necrosis factor-α levels were elevated (0.66 vs 0.55 pg/ul) while monocyte chemoattractant protein-1 and IL-6 levels were lower in ...
CSF/serum albumin index 我們有專家為這個問題所編寫的解答! 27. Given the following results, calculate the IgG index: CSF IgG, 50 mg/dL; serum IgG, 2 g/dL; CSF albumin, 70 mg/dL; serum albumin, 5 g/dL. A. 0.6 B. 6.0 C. 1.8 D. 2.8 ...
Finally, OCGBs provide only a qualitative, and not quantitative, information about intrathecal B-cell activation [46]. A quantitative measure of intrathecal IgG production, such as IgG index (CSF/serum IgG ratio divided by CSF/serum albumin ratio), is less diagnostically sensitive than OCGBs and...
“a characteristic that is objectively measured and evaluated as an indicator of normal biological processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention” [3]. A biomarker is thus epistemologically distinct in its objectivity from findings arising from structured ...
bodyweight of the mice, and this effect was reversed by both CSEI and Tα1 treatment (P < 0.05; Table1). In addition, CTX resulted in splenomegaly and thymus reduction in the mice; in contrast, both CSEI and Tα1 reversed these abnormalities to normal levels (P < 0.05; ...
The same immunization was attempted in the presence of anti-CTLA4 antibody (9D9 IgG2b) (Fig.1a, right panels). The isotype control antibody (mouse IgG2b isotype control) did not have any effect on tumor rejection in over 10 experiments. The best tumor rejection (100%) was observed in mi...
Slope test was performed to test the relationship between PLX3397 dose and restoration of network gene expression back to “normal.” The test was performed using “smartr” version 3.4.3, R package, with null hypothesis that there is no difference in the slopes obtained from two doses of ...
(ii) associated with CSF-1R activity, or (iii) characterized by activity (normal or abnormal) of CSF-1R; or (2) reducing or inhibiting the activity of CSF-1R; or (3) reducing or inhibiting the expression of CSF-1R. In another non-limiting embodiment, the term “a therapeutically ...
Primary antibodies were diluted in PBS+5% Normal Goat Serum (NGS). Single immunostaining consisted of overnight incubation at 4° C. with the unconjugated mAb anti-human GM-CSF antibody (clone 3209.1; R&D Systems) or IgG isotype control for biopsies from human subjects and rat α-F480 (clone...