7,8 Other individuals have a benign form of MCI and show no progression of symptoms, while some eventually develop other types of dementia.9 Biochemical changes in the brain are reflected in the cerebrospinal fluid (CSF), and intense research efforts have been made to develop biomarkers for ...
Full size image Taken together, our results demonstrate that senescent cells secrete bFGF and GM-CSF, which in turn promote breast cancer cell motility. The JNK pathway mediates senescent cell-induced breast cancer cell migration We next investigated the signaling pathway in breast cancer cells which...
Full size image These results indicate that senescent cell-secreted GM-CSF and bFGF induce breast cancer cell migration by activating the signaling pathway involving both JNK1 and JNK2 in cancer cells. Senescent fibroblast cells promote breast cancer metastasis in xenograft tumor models To investigate...
Granulocyte-macrophage colony stimulating factor (GM-CSF) is a cytokine with a wide range of biological effects that span innate and adaptive immunity processes. As our knowledge of the biology of GM-CSF improves, its potential as a therapeutic target in
Full size image Biochemical pregnancy rate Four studies reported the biochemical pregnancy rate and included 469 RIF patients, 228 of whom were in the study group and 241 of whom were in the control group. A fixed-effects model was used for data synthesis, and the results indicated that G-C...
Full size image Western blot confirmed the presence of GM-CSF in reproductive organs and derived fluids and in mature pig spermatozoa Western blot identified three different forms of GM-CSF in the pig reproductive tissues, with molecular weights of ~ 40, 31 and 15 kDa, see Fig. 6(a1)...
Other cell types, such as endothelium and fibroblasts, also secrete GM-CSF in response to TNF-α, IL-2, IL-1, and IFN-γ. GM-CSF stimulates growth of macrophages, granulocytes and dendritic cells. GM-CSF is found as a membrane-bound form and also as a complex associated with the ...
in form of inclusion body and was approximately 34 ku.Western Blot analysis showed that it could be specifically recognized by the rabbit sera to chicken GM-CSF.Results of MTT assay confirmed that it can enhance chicken bone marrow cell proliferation obviously.These results demonstrated that the E...
Full size image Levels of G-CSFR expression were decreased by stroke to less than 50% relative to untreated Sham animals. G-CSF treatment can increase expression of G-CSFR by greater than 1.9 fold and 2.1 fold in the frontal brain and middle brain regions respectively relative to vehicle trea...
may help multiple myeloma cells move from the patient's bone marrow to the blood where they may be more sensitive to treatment with melphalan. It is not yet known whether adding XMO2 Filgrastim (Granix) to melphalan before a stem cell transplant will work better than melphalan alone in treati...