Robust reconstruction of the skull base after endoscopic endonasal approaches (EEA) for parasellar lesions is paramount to preventing postoperative cerebrospinal fluid (CSF) leak. Traditionally, multilayer closure is performed, composed of a fat graft, subdural underlay with adjunct bony substitutes, ...
2022 saw the regulatory approval of the first in vitro diagnostic test for Alzheimer’s disease (AD), 35 years after the first published attempt to measure beta-amyloid peptides in human cerebrospinal fluid (CSF) in people with clinically diagnosed AD dementia [1] and 10 years after the first...
The objective of this study was to monitor the time course of glutamate, and associated enzymes, such as glutamate–oxaloacetate transaminase (GOT1), glutamate-pyruvate transaminase (GPT) in cerebrospinal fluid (CSF) and serum, shortly after SAH, and to assess their prognostic value. A total of...
Undisturbed brain fluid distribution with obesity To elucidate whether the brain water dispersed differentially with obesity, we performed MRI analysis on the two rodent cohorts (Fig. 3A-B). Initial analysis demonstrated a slightly reduced brain volume in the obese Zucker rats (2091 ± 31 mm3...
Currently, there is no specific diagnostic test for MS. Although magnetic resonance imaging (MRI) scans of the brain and spinal cord, evoked potentials and cerebrospinal fluid (CSF) analysis can be of aid, the diagnosis is still based on clinical criteria [5,6]. Along with epidemiological stud...
219:92), while several studies measuring cytokines in BAL fluid of asthmatic patients have found an increase in GM-CSF (Gajewska (2003) Curr Drug Targets Inflamm Allergy 2:279). [0011] Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease for which there is ample evidence ...
In this study, we analyze data from a 10-year period of endoscopic anterior skull base surgery in our institution to identify characteristics associated with increased risk of postoperative cerebrospinal fluid leak. Management of these leaks is also described Methods: A retrospective chart review was ...
Cerebrospinal fluid (CSF) leaks are among the most common complications of this approach. Here we review consecutive skull base resections using EEA in pediatric patients at a single institution, to identify potential risk factors for this surgical complication. Methods: A retrospective chart review ...
Rösler N., Wichart I., and Jellinger K. A. (1996) Total tau protein immunoreactivity in lumbar cerebrospinal fluid of patients with Alzheimer’s disease. J. Neurol. Neurosurg. Psychiatry 60, 237–238. PubMed Google Scholar Kanai M., Matsubara E., Isoe K., Urakami K., Nakashima K...
Analysis of variance BBB: Blood-brain barrier BEC: Brain endothelial cells BMEC: Brain microvascular endothelial cells cART: Combination antiretroviral therapy GM-CSF: Granulocyte-macrophage colony-stimulating factor HAART: Highly active antiretroviral therapy HAD: HIV-1-associated dementia HIV-...