Our approach was to use subject-specific MRI-derived CNS compartment volumes to better model transport of CSF from the cranial subarachnoid space (SAS) to the lumbar SAS. Although we do not directly measure or model “glymphatic” fluxes (i.e., flow within the perivascular space and brain ...
although this is a simplification28,29. Each heartbeat and breath also induces substantial oscillatory CSF flow30,31,32. The complicated flow patterns of the CSF resulting from these pulsations are observable by MRI velocimetry and enhance mass transport in the CNS33,34,35. The presence...
We thank CPT of Verona University, which has been instrumental for access to flow cytometry/cell analysis and the genomic/transcriptomic and the computational platforms. We thank Stefano Ugel and Vincenzo Bronte (University of Verona) for help with cancer patient recruitment. Author contributions F.P...