Pneumococcal meningitis propagates to the skull. Skull channels are conduits for S. pneumoniae into the marrow. S. pneumoniae propagation in the CSF induces skull hematopoiesis. Every day, the human ventricular choroid plexus produces most of the 500ml of CSF. CSF outflow occurs via several routes...
Cell counts, bacterial smears, and cultures of samples of cerebrospinal fluid are done when an inflammatory process or infection of the meninges is suspected. Since the cerebrospinal fluid contains nutrient substances such as glucose, proteins, and sodium chloride, and also some waste products such ...
Purpose: To examine the predictive ability of CSF cytokines in the diagnosis of bacterial meningitis in infants. Methods: This prospective, multi-center study included infants 120 mg/dL or CSF glucose <20 mg/dL (consensus definition). Results: 322 subjects had a median GA of 36 wks [inter...
Pediatric bacterial meningitis is a life-threatening illness that results from bacterial infection of the meninges and leaves some survivors with significant sequelae. Therefore, meticulous attention must be paid to appropriate treatment and monitoring o
Myelin basic protein—seen when the covering of nerves (myelin) breaks down, such as with multiple sclerosis CSF lactate—often used to distinguish between viral and bacterial meningitis; the level will usually be increased with bacterial and fungal meningitis while it will remain normal or only sl...
A serum procalcitonin level >0.5 ng/ml had high sensitivity and specificity ( 90.1% and 97.1% respectively) in the diagnosis of bacterial meningitis. Conclusion: CSF procalcitonin level seems to be a valuable marker in differentiating between bacterial and viral meningitis....
1104 QUANTITATIVE MEASUREMENT OF C-REACTIVE PROTEIN (CRP) IN CEREBROSPINAL FLUID (CSF) OF PATIENTS WITH BACTERIAL MENINGITISPediatric Research publishes original papers, invited reviews, and commentaries on the etiologies of diseases of children and disorders of development, extending from molecular biology...
(2) detection of anti-NMDA receptor antibodies in CSF or serum. Exclusion criteria were as follows: (1) HIV infection, meningitis, brain abscess, prion diseases, cerebral malaria, brain tumor, or a diagnosis of a non-infectious central nervous system disease, such as acute demyelinating ...
bacterial live-dead reporter strain to assess macrophage antimicrobial capacity at a single cell level, we find that these macrophages display significant cell-to-cell variability in antibacterial capacity. We leveraged this natural variation in antimicrobial function to define the features of the ...
and Dajani, A.S.: Diffusion of moxalactam into CSF of children with bacterial meningitis. Pediatric Research 15: 623 (1981a).Thirumoorthi MC, Buckley JA, Kauffman RE, Dajani AS: Diffusion of moxalactam into CSF of children with bacterial meningitis. Pediatr Res 15:623, 1981. (Abst.)...