L. (1987) Relationships between CSF drug concentration receptor binding characteristics and pharmacokinetic and pharmacodynamic properties of selected 1,4 substituted benzodiazepines. Clin. Pharmacokinet. 12: pp. 179-190Colburn, W. F., and Jack, M. L. (1987). Relationships between CSF drug ...
In the trial, the first serum and cerebrospinal fluid concentration tests were performed 24 hours after initiation of dosing, and dose adjustments were made at the 48-hour time point. This was followed by a second drug concentration test at 72 hours, followed by dose adjustment at the 96-...
PLX5622 是一种 CSF1R 抑制剂 (IC50=0.016 µM),具体选择性、口服活性和血脑屏障通透性。PLX5622 可以引起持续和特异性的小胶质细胞的消除。 规格价格库存数量 1 mg ¥ 428 现货 5 mg ¥ 977 现货 10 mg ¥ 1,633 现货 25 mg ¥ 2,747 ...
zero to infinity;CL/F,apparent serum clearance after SC administration of dose;MRT,Mean residence time; Tc<2ng/ml,time of plasma concentration less than 2ng/ml which supposed to be as the lowest drug effective concentration.The Tc<2ng/ml for the dose 12.5μg/kg of PEG30-rhG-CSF is ...
Fox E, Bungay PM, Bacher J, et al. Zidovudine concentration in brain extracellular fluid measured by microdialysis: steady-state and transient results in rhesus monkey. J Pharmacol Exp Ther. 2002;301(3):1003–11. PubMedCAS Thomas SA, Segal MB. The transport of the anti-HIV drug, 2′,3...
The toxic concentration of H2 receptor antagonists, such as cimetidine (CIM), ranitidine(RAN) and famotidine(FAM) in the cerebrospinal fluid (CSF) and ... M Shimokawa,K Yamamoto,Y Sawada,... - 《Drug Metabolism & Pharmacokinetics》 被引量: 2发表: 1993年 Effect of Renal Failure on Neurotox...
The concentration of NVP-BEP800 which inhibits Hsp90β by 50% is determined from the competition curve. 别名 PLX-3397 化学信息 分子量 417.81 分子式 C20H15ClF3N5 CAS No. 1029044-16-3 Smiles FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncc(Cl)cc34)cn2)cn1 密度 1.458 g/cm3 (Predicted) 储存&...
Recommend dissolved to store concentration with sterile water (or PBS), add 200ml water to reach the concentration at 250μl/ml is a good idea. Dilution: Proposal to diluted withCellGenix®Serum free Media. And please add carrier protein when diluted with sterilewater or PBS, wich prevent ...
FC The suggested concentration for this CSF-1R antibody (clone AFS98) antibody for staining cells in flow cytometry is ≤ 0.25 μg per 106 cells in a volume of 100 μl. Titration of the reagent is recommended for optimal performance for each application. Additional Applications Reported In Lit...
Cerebrospinal fluid concentration of brain-derived neurotrophic factor and cognitive function in non-demented subjects. PLoS ONE 4, e5424 (2009). Article ADS Google Scholar Pan, S., Mayoral, S. R., Choi, H. S., Chan, J. R. & Kheirbek, M. A. Preservation of a remote fear memory ...