In neuro-oncology, morphological detection of tumor cells in cerebrospinal fluid (CSF cytology) or of soluble factors in CSF or blood (tumor markers) is used for diagnosis, tumor staging, and therapy decisions. CSF cytology may be particularly useful for the detection of leptomeningeal spread of ...
Identification of leptomeningeal disease in aggressive B-cell non-Hodgkin's lymphoma: improved sensitivity of flow cytometry. Here, we evaluate the sensitivity and specificity of a new 11-parameter flow cytometry (FCM) approach versus conventional cytology (CC) for detecting neopl... S Quijano,A ...
- 《Cytometry Part A the Journal of the International Society for Analytical Cytology》 被引量: 32发表: 2015年 Reduction of intra- and interlaboratory variation in CD34[sup +] stem cell enumeration using stable test material, standard protocols and targeted training. Summary. The European Working ...
Diagnosis of primary diffuse large B-cell lymphoma of the central nervous system (PCNSL) is challenging and often delayed. MRI imaging, CSF cytology and flow cytometry have a low sensitivity and even brain biopsies can be misleading. We report three cases of PCNSL with various clinical ...
In a retrospective cohort of 54 PCNSL cases tested at diagnosis or relapse, we evaluated the contribution of immunoglobulin heavy chain (IGH) gene clonality and MYD88 L265P detection on both CSF cell pellets and supernatants, in comparison with cytology, flow cytometry, interleukin (IL)‐10 and...
Current diagnostic methods include neuroimaging, CSF cytology, FDG-PET scans, and biopsies. Building upon the success of the IL-10:IL-6 ratio as a diagnostic biomarker in intraocular lymphoma, this study investigates its potential in PCNSL diagnosis. CSF IL-10:IL-6 ratio emerges as a promising...
^9% respectively.Conclusion The cytology measurement of the CSF is one of the reliable methods which are used to diagnose CNSL,especially to diagnose those whose clinical symptoms are negtive.This method is very valuable for the early diagnosis,prognostic judgement and therapeutic monitor of the CN...
The authors reported low sensitivity for CSF cytology (2%–32%), which is increased when combined with flow cytometry. Studying β2-microglobulin, and immunoglobulin heavy chain rearrangement as well as lactate dehydrogenase isozyme 5 in the CSF has improved CSF cytology sensitivity but not ...