Preclinical work using mouse models would be useful to explore novel CSF biomarkers; however, detailed characterization of CSF has been challenging due to the difficulty in collecting large amount of CSF from mice. Here, we developed a novel technique that allows consistent recovery of CSF in the...
(CSF) inflow into the cerebral glymphatic system (GS) in Alzheimer's disease (AD) model mice at different ages via 9.4 T dynamic contrast-enhanced (DCE)-MRI, in order to elucidate the alterations through the cerebral GS clearance with age, and the role of aquaporin 4 (AQP4) in the ...
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M.A.G. isolated OPCs from mice with loxP-flanked Srf, and M.I. and M.S.H. assisted with cell culture experiments. A.C.Y., A.R.M. and T.I. preformed labelled CSF and Fgf17 experiments. S.R.S. assisted with CSF collection. R.P. and B.L. assisted with bioinformatic analysis...
Mammalian sleep has been implicated in maintaining a healthy extracellular environment in the brain. During wakefulness, neuronal activity leads to the accumulation of toxic proteins, which the glymphatic system is thought to clear by flushing cerebral spinal fluid (CSF) through the brain. In mice, ...
Here, we performed serial CSF sample collection from conscious and freely moving mice in a longitudinal study design to identify the proteome changes closely associated with changes in brains states following administration of HNK over time. Changes in the CSF proteome and differential expression of ...
Use cautiously in: • renal or hepatic insufficiency, fluid retention, pulmonary disorders, pulmonary infiltrates, heart failure, leukocytosis, transient supraventricular arrhythmias • cancer patients undergoing sargramostim-mobilized PBPC collection • patients receiving purged bone marrow or previously exp...
collected throughout disease progression from R6/2 transgenic mice with CAG repeats of 200 or 90 codons (R6/2:Q200 and R6/2:Q90), zQ175 knock-in mice and YAC128 transgenic mice, along with their respective wild-type littermates. Neurofilament light chain and total-Tau concentrations were ...
Nevertheless, immune cells, especially microglia, are also beneficial for brain homeostasis with neuro-protective functions and may contribute to stress adaptation, as demonstrated by others and us in mice [19, 20]. Colony stimulating factor 1 receptor (CSF1R) is a receptor tyrosine kinase crucial...
we found that plasma Aβ(1–42) concentration increases with age, while the concentration of Aβ(1–42) in the cerebrospinal fluid (CSF) decreases in APPswe, PS1M146V and TauP301L transgenic (3xTg-AD) mice, if measurements were made before formation of ThS-positive plaques in the brain...