Introduction Crystallographyhas been, and to this day remains an incredibly successful method for the determination of high-resolution macromolecular and small molecule structures. While the vast majority ofdiffractionexperiments incrystallographymake use of X-rays, there is a key bottleneck associated with...
a neutral buoyancy solution can be prepared using 1.4M sucrose inG0buffer. A difficulty that arises with the sucrose-containing solution is that theviscosityincreases with the amount of sucrose, and consequently, the liquid pressure in the jet needs to be increased. This can lead to an unstable...
By rotating the crystal about such an axis Op (fig. 3) through an angle of 120° those faces which are not perpendicular to the axis occupy interchangeable positions; for example, the face a 1 a 3 a 2 comes into the position of a 2 a 1 a 3, and a 2 a 1 a 3 to a3a2a1. D...
Automated Structure Solution With autoSHARP Clemens Vonrhein, Eric Blanc, Pietro Roversi, Gérard Bricogne Pages 215-230 Introduction to Macromolecular Refinement Dale E. Tronrud Pages 231-253 Quality Control and Validation Gerard J. Kleywegt Pages 255-272 Crystallographic Software Stephen...
et al. Ultrafast myoglobin structural dynamics observed with an X-ray free-electron laser. Nat. Commun. 6, 6772 (2015). Article ADS Google Scholar Lee, Y. et al. Ultrafast coherent motion and helix rearrangement of homodimeric hemoglobin visualized with femtosecond X-ray solution scattering. ...
et al. Ultrafast myoglobin structural dynamics observed with an X-ray free-electron laser. Nat. Commun. 6, 6772 (2015). Article ADS Google Scholar Lee, Y. et al. Ultrafast coherent motion and helix rearrangement of homodimeric hemoglobin visualized with femtosecond X-ray solution scattering. ...
Introduction An understanding of macromolecular structure is crucial for insight into the function of complex biological systems. Despite recent advances in single-particle cryo-electron microscopy (cryo-EM), the vast majority of high-resolution structures are determined by crystallographic methods (http:/...
The remarkable advances in our understanding of the molecular action of drugs owe no small part to x-ray crystallography. Technological progress in this field has raised realistic expectations for the structure solution of drug targets. This chapter provides an introduction to this important subject, ...
MutharasappanNachiappan, ...JeyaramanJeyakanthan, inMolecular Docking for Computer-Aided Drug Design, 2021 1Introduction X-raycrystallographyis a versatile tool in structural biology to determine the atomic and molecular structure of a crystal. The basic principle in working ofX-ray crystallographyis...
it is deposited under two different COD identifiers. The rationale here is that a COD record reports an instance of the crystal structure solution reported somewhere, and all such cases must be represented in the database. Further reduction of the multiple records is the responsibility of the COD...