Crystal structure of rhodopsin: a template for cone visual pigments and other G protein-coupled receptors. Biochim. Biophys. Acta 2002;1565:168-82. [PubMed: 12409193]Stenkamp, R.E. et al. (2002) Crystal structure of rhodopsin: a template for cone visual pigments and other G protein-...
Structural studies of active states of the visual pigment rhodopsin, a G protein-coupled receptor, have previously been limited to apoprotein or opsin forms that do not contain the agonist all-trans-retinal. Two groups now report structures that reveal m
Here we present the 2.4-Å-resolution structure of HeR from an uncultured Thermoplasmatales archaeon SG8-52-1 (GenBank sequence ID LSSD01000000). Structural and biophysical analyses reveal the similarities and differences between HeRs and type-1 microbial rhodopsins. The overall fold of HeR ...
生物界中很多生物体内表达可以感光的蛋白,其中包括7次穿膜的各种opsins,比如人类视网膜上的感光蛋白rhodopsin,人类的rhodopsin是一些G protein coupled receptors,吸收光子后构象改变而激活细胞内部的下游通路从而使细胞电位变化而生成感光信号。不同于人类的感光蛋白,一些低级生物中也表达结构类似的感光蛋白,但是这些蛋白吸收...
Crystal Structure of Rhodopsin: A G‐Protein‐Coupled ReceptorSingle-crystal structure validation with the program PLATONCrystal structure of the nucleosome core particle at 2.8 A resolution.SHELXL-93. Program for crystal structure refinementSHELXTI93, Program for crystal structure refinementSIR...
Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations ChemInform Abstract: Crystal Structure of Rhodopsin: A G‐Protein‐Coupled Receptor Spek, A. L. Single-crystal structure validation with the program PLATON. J. Appl. Crystallogr. 36, 7-13 ...
The βAR structure differs from rhodopsin in having weaker interactions between the cytoplasmic ends of transmembrane (TM)3 and TM6, involving the conserved E/DRY sequences. These differences may be responsible for the relatively high basal activity and structural instability of the βAR, and ...
The beta2AR structure differs from rhodopsin in having weaker interactions between the cytoplasmic ends of transmembrane (TM)3 and TM6, involving the conserved E/DRY sequences. These differences may be responsible for the relatively high basal activity and structural instability of the beta2AR, ...
X-ray structure of sensory rhodopsin II at 2.1- resolution ant A, Nollert P, Neutze R, Landau EM, Pebay-Peyroula E, Navarro J (2001a) X-ray structure of sensory rhodopsin II at 2.1 Å resolution... A Royant,P Nollert,K Edman,... - 《Proceedings of the National Academy of...
Design of a light-gated proton channel based on the crystal structure ofCoccomyxarhodopsin. The light-driven proton pumpCoccomyxa subellipsoidearhodopsin (CsR) provides-because of its high expression in heterologous host cells-an opportunity to study active proton transport under controlled electrochemical...