Crystal structure of cas9 in complex with guide RNA and target DNA. Cell. 2014; 156:935-949. [PubMed: 24529477]Nishimasu, H, Ran, FA, Hsu, PD, Konermann, S, Shehata, SI, Dohmae, N, Ishitani, R, Zhang, F, Nureki, O (2014) Crystal structure of Cas9 in complex with guide RNA...
Crystal structure of Cas9 in complex with guide RNA and target DNA Cell, 156 (2014), pp. 935-949 View PDFView articleView in ScopusGoogle Scholar Nishimasu et al., 2015 H. Nishimasu, L. Cong, W.X. Yan, F.A. Ran, B. Zetsche, Y. Li, A. Kurabayashi, R. Ishitani, F. Zhang,...
Crystal structure of the catalytic domain of HIV-1 restriction factor APOBEC3G in complex with ssDNA Atanu Maiti, Wazo Myint, Tapan Kanai, Krista Delviks-Frankenberry, Christina Sierra Rodriguez, Vinay K. Pathak, Celia A. Schiffer & Hiroshi Matsuo Nature Communications volume 9, Artic...
Here we present the crystal structure of a complex of a cytidine deaminase with ssDNA bound in the active site at 2.2 Å. This structure not only visualizes the active site poised for catalysis of APOBEC3A, but pinpoints the residues that confer specificity towards CC/TC motifs. The APOBEC...
three-dimensional structure of protein to studying the structure of various biological macromolecules and complexes, and focus more on the relationship between structure and function. In pharmaceutical R&D, protein crystallographic structure is widely and significantly used in structure-based new drug design...
Within organisms, genetic information generally is carried in chromosomes, where it is represented in the chemical structure of particular DNA (deoxyribonucleic acid) molecules. Read more ...DNA Deoxyribonucleic acid DNA) is a molecule that carries the genetic instructions used in the growth, ...
interaction mode on Cas9 will help us elucidate the diversity in the inhibitory mechanisms of the Acr protein family. DOI: 10.1002/pro.4214 关键词: AcrIIC4;Anti-CRISPR proteins;CRISPR-Cas system;Crystal structure;Gene editing; 年份: 2021
Understanding the physico-chemistry and structural features of TRXs hence appears as a powerful entry point to estimate the physiological significance of TRX-dependent regulation, along with specificity towards target proteins [39]. Here, we describe the novel crystal structure of chloroplastic TRX f2 ...
molecules Article A Glimepiride-Metformin Multidrug Crystal: Synthesis, Crystal Structure Analysis, and Physicochemical Properties Xufei Bian 1,†, Lan Jiang 2,†, Zongjie Gan 1, Xiaoshu Guan 1, Li Zhang 1, Linhong Cai 1 and Xiangnan Hu 1,* 1 Department of Medicinal Chemistry, School of ...
A brain structure called the amygdala grows too fast in babies who are diagnosed with autism by age 2, a new study suggests. The study researchers found that this overgrowth occurs between 6 and 12 months of age, before children are typically diagnosed with autism. The...